Strain Data Sheet

RBRC01720

Strain Information

Image
BRC No.RBRC01720
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.FVB-Tg(Itgax-DTR/EGFP)57Lan/Rbrc
Former Common nameC57BL/6-CD11c-DTR
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Appearance
Strain development
Strain description
Colony maintenance
References
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer E G, Littman D R, Lang R A
Immunity, 17, 211-220 (2002). 12196292

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFPGreen Fluorescent Protein (Aequorea victoria)UN
HBEGFheparin-binding EGF-like growth factor (monkey)UNHBEGFmouse Itgax promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal CD8-positive, alpha-beta T cell differentiation(MP:0008080)

  • abnormal NK T cell physiology(MP:0008042)

  • abnormal NK cell physiology(MP:0010766)

  • abnormal T cell activation(MP:0001828)

  • abnormal alveolar macrophage morphology(MP:0008245)
    • more 37 phenotypes
  • abnormal circulating cytokine level(MP:0010210)

  • abnormal professional antigen presenting cell physiology(MP:0002452)

  • abnormal response to infection(MP:0005025)

  • abnormal susceptibility to infection(MP:0001793)

  • cachexia(MP:0005150)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased NK T cell number(MP:0008040)

  • decreased T cell number(MP:0005018)

  • decreased circulating interferon-gamma level(MP:0008578)

  • decreased circulating interleukin-12 level(MP:0008618)

  • decreased cytotoxic T cell cytolysis(MP:0005079)

  • decreased dendritic cell number(MP:0008127)

  • decreased gamma-delta T cell number(MP:0008347)

  • decreased interferon-gamma secretion(MP:0008567)

  • decreased interleukin-12b secretion(MP:0008670)

  • decreased interleukin-17 secretion(MP:0008682)

  • decreased interleukin-4 secretion(MP:0008700)

  • decreased leukocyte cell number(MP:0000221)

  • decreased macrophage cell number(MP:0003884)

  • decreased neutrophil cell number(MP:0000222)

  • decreased physiological sensitivity to xenobiotic(MP:0008874)

  • decreased susceptibility to autoimmune diabetes(MP:0004804)

  • decreased susceptibility to bacterial infection(MP:0002411)

  • endocrine/exocrine gland phenotype(MP:0005379)

  • immune system phenotype(MP:0005387)

  • impaired natural killer cell mediated cytotoxicity(MP:0005070)

  • impaired neutrophil recruitment(MP:0008719)

  • increased interferon-gamma secretion(MP:0008566)

  • increased monocyte cell number(MP:0000220)

  • increased neutrophil cell number(MP:0000219)

  • increased susceptibility to bacterial infection(MP:0002412)

  • increased susceptibility to induced morbidity/mortality(MP:0009763)

  • increased susceptibility to viral infection(MP:0002418)

  • increased tumor necrosis factor secretion(MP:0008560)

  • insulitis(MP:0004031)

  • premature death(MP:0002083)

  • sepsis(MP:0005044)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Itgax promoter, monkey heparin-binding EGF-like growth factor(hbEGF) cDNA, jellyfish Green Fluorescence Protein (GFP) cDNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 17, 211-220 (2002).Research Purpose only. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEVELOPER (Dr. Dan Littman).
    DepositorShigeo Koyasu (Keio University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data