Strain Data Sheet

RBRC01714

Strain Information

Image
BRC No.RBRC01714
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CD2-Maf)50Staka/StakaRbrc
Former Common nameC57BL/6J-VA-s-c-Maf Tg line50, VA-s-c-Maf Tg line 50
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.
Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, Yamada A, Maeda A, Matsuno F, Hata H, Suzuki A, Imagawa S, Mitsuya H, Esumi H, Koyama A, Yamamoto M, Mori N, Takahashi S
Cancer Res., 66, 812-819 (2006). 16424013

Health Report

Examination Date / Room / Rack2023/05/08Room:2-検Rack:G
2023/02/06Room:2-検Rack:G
2022/11/07Room:2-検Rack:G

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mafavian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homologUNMafhuman CD2 promoter and CD2 LCR
  • Ayme-Gripp syndrome(MedGEN)

  • cataract 21 multiple types(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal acute inflammation(MP:0002498)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased double-positive T cell number(MP:0005092)

  • enlarged spleen(MP:0000691)
    • more 8 phenotypes
  • increased DN3 thymocyte number(MP:0010133)

  • increased T cell derived lymphoma incidence(MP:0002024)

  • increased double-negative T cell number(MP:0005090)

  • increased kidney tumor incidence(MP:0010294)

  • increased liver tumor incidence(MP:0008019)

  • increased lung tumor incidence(MP:0008014)

  • increased lymphoma incidence(MP:0012431)

  • increased tumor incidence(MP:0002020)
    • Detailed phenotype data

    Ordering Information

    Donor DNAVA vector (Human CD2 promoter, Human CD2 LCR (Locus Control Region), Mouse c-Maf cDNA
    Research applicationCancer Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cancer Res., 66, 812-819 (2006).
    DepositorSatoru Takahashi (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data