Strain Data Sheet

RBRC01688

Strain Information

Image
BRC No.RBRC01688
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Pcdha<tm3Tyag>/TyagRbrc
Former Common nameBdAB, Pcdha [Delta]CR, CNR [Delta]CR, [Delta]CR, CNR BdAB
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University in 2001.
Strain descriptionPcdha deltaCR mice. Germ line cre-mediated tras-allelic recombination between CNR G1loxP and CNR-delta B (RBRC01693), resulting in the deletion of CR1, CR2 and CR3a. Homozygous mice show no obvious abnormality.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6J(Crlj)]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pcdhaprotocadherin alpha cluster18Pcdhatargeted mutation 3, Takeshi Yagi
loxPphage P1 loxP18loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal cingulate gyrus morphology(MP:0004167)

  • abnormal dentate gyrus morphology(MP:0000812)

  • abnormal dorsal striatum morphology(MP:0004102)

  • abnormal entorhinal cortex morphology(MP:0006300)
    • more 15 phenotypes
  • abnormal globus pallidus morphology(MP:0004081)

  • abnormal hippocampus morphology(MP:0000807)

  • abnormal lateral geniculate nucleus morphology(MP:0004165)

  • abnormal medial geniculate nucleus morphology(MP:0008930)

  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal primary motor cortex morphology(MP:0012448)

  • abnormal serotonergic neuron morphology(MP:0003877)

  • abnormal serotonin level(MP:0005322)

  • abnormal substantia nigra morphology(MP:0000836)

  • abnormal thalamus morphology(MP:0000832)

  • decreased body weight(MP:0001262)

  • increased grooming behavior(MP:0001441)

  • increased serotonin level(MP:0010069)

  • nervous system phenotype(MP:0003631)

  • skin lesions(MP:0001212)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP, mouse Pcdha genomic DNA
    Research applicationCell Biology Research
    Cre/loxP system
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data