Strain Data Sheet

RBRC01670

Strain Information

Image
BRC No.RBRC01670
TypeInbred
SpeciesMus musculus
Strain nameDDD/Sgn
Former Common name
H-2 Haplotype
ES Cell line
Background strainDDD
Appearance
Strain developmentAccording to Tanaka Matsuzawa (1990) "Inbreeding of dd mice maintained at Denken was commenced in 1957 and the resulting inbred strain was named DDD after dd at Denken. The ancestors of dd mice had come from Germany.F164
Strain descriptionMammary tumours 8% at 14 months in virgin and 14% at 14 months in force-bred females. Mammary tumour virus carried by the strain is probably of plaque-inducing group found in DD, RIII and BR6 but not in C3H (Matsuzawa et al., 1974., 1974). Develop a high incidence of heritable hydronephrosis, with a higher incidence observed in males and females. This appears to be caused by an abnormally high internal pressure in the renal pelvis leading to incomplete protection against the vesico-urethral reflex (Mannen et al 1991). Host of a very stable, transplantable pregnancy-dependent mammary tumour TPDMT-4 (Matsuzawa and Yamamoto, 1975). Resistant to the development of uterine tumours following treatment with DMBA at 4-weeks of age (cf 3/6) (Tsubura et al, 1993). High incidence of lethality among F1 Dh/+ male mice resulting from a cross between DDD females and DH-Dh/+ males, however, this is not observed in the reciprocal cross (Suto et al, 1996).
Colony maintenance
References
High lethality of F1 (Dh/+) male mice from the cross between DDD female and DH (Dh/+) male.
Suto J, Wakayama T, Imamura K, Goto S, Fukuta K
Exp. Anim., 45, 99-101 (1996). 8689589

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • hydronephrosis(MP:0000519)

  • neonatal lethality(MP:0002058)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHideo Goto (National Institute of Agrobiological Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T.
    Genetic variation of melatonin productivity in laboratory mice under domestication.
    Proc Natl Acad Sci U S A 107(14) 6412-7(2010) 20308563