Strain Data Sheet

RBRC01657

Strain Information

Image
BRC No.RBRC01657
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.B6CB-Grid2<tm1Mim>/MimRbrc
Former Common nameGluRδ2KO mouse
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice.
Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, Takayama C, Inoue Y, Kutsuwada T, Yagi T, Kang Y, et a l
Cell, 81, 245-252 (1995). 7736576

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Grid2glutamate receptor, ionotropic, delta 26Grid2targeted mutation 1, Masayoshi Mishina
  • autosomal recessive spinocerebellar ataxia 18(DisGeNET, MedGEN)
    • neoneomycin resistance gene (E. coli)6mouse phosphoglycerate kinase promoter (PGK promoter)
  • autosomal recessive spinocerebellar ataxia 18(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synapse formation(MP:0004996)

  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal GABA-mediated receptor currents(MP:0004008)

  • abnormal Purkinje cell innervation(MP:0003894)

  • abnormal Purkinje cell morphology(MP:0000877)
    • more 23 phenotypes
  • abnormal action potential(MP:0005402)

  • abnormal cerebellar molecular layer(MP:0000889)

  • abnormal cerebellum morphology(MP:0000849)

  • abnormal excitatory postsynaptic currents(MP:0002910)

  • abnormal eye blink conditioning behavior(MP:0002807)

  • abnormal eye movement(MP:0001389)

  • abnormal gait(MP:0001406)

  • abnormal locomotor activation(MP:0003313)

  • abnormal miniature inhibitory postsynaptic currents(MP:0009435)

  • abnormal motor coordination/balance(MP:0001516)

  • abnormal optokinetic reflex(MP:0009619)

  • abnormal reflex(MP:0001961)

  • abnormal response to injury(MP:0005164)

  • abnormal vestibuloocular reflex(MP:0004844)

  • absent long-term depression(MP:0001899)

  • ataxia(MP:0001393)

  • decreased locomotor activity(MP:0001402)

  • decreased vertical activity(MP:0002757)

  • head tilt(MP:0005191)

  • impaired coordination(MP:0001405)

  • impaired righting response(MP:0001523)

  • increased prepulse inhibition(MP:0009141)

  • thin cerebellar molecular layer(MP:0000890)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse GluRδ2 subunit genomic DNA, mouse PGK promoter, E. coli neo
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for first publication if no publication is made within the TWO years.
    DepositorMasayoshi Mishina (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data