Strain Data Sheet

RBRC01530

Strain Information

Image
BRC No.RBRC01530
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Il6st<tm1Thir>/ThirRbrc
Former Common nameWH, C57BL/6 gp130<WH/WH>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
T Ohtani, K Ishihara, T Atsumi, K Nishida, Y Kaneko, T Miyata, S Itoh, M Narimatsu, H Maeda, T Fukada, M Itoh, H Okano, M Hibi, T Hirano
Immunity, 12, 95-105 (2000). 10661409

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.
Toru Atsumi, Katsuhiko Ishihara, Daisuke Kamimura, Hideto Ikushima, Takuya Ohtani, Seiichi Hirota, Hideyuki Kobayashi, Sung-Joo Park, Yukihiko Saeki, Yukihiko Kitamura, Toshio Hirano
J. Exp. Med., 196, 979-990 (2002). 12370259

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il6st
MGI:96560		interleukin 6 signal transducer13Il6st<tm1Thir> targeted mutation 1, Toshio Hirano
  • hyper-IgE recurrent infection syndrome 4, autosomal recessive(MedGEN)
    • neo neomycin resistance gene (E. coli)13

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal B cell physiology (MP:0002459)

  • abnormal T cell activation (MP:0001828)

  • abnormal T cell clonal deletion (MP:0005002)

  • abnormal action potential (MP:0005402)

  • abnormal bone structure (MP:0003795)
    • more 33 phenotypes
  • abnormal channel response intensity (MP:0003486)

  • abnormal dendritic cell antigen presentation (MP:0002455)

  • abnormal myocardial fiber physiology (MP:0004215)

  • abnormal osteoblast physiology (MP:0005006)

  • abnormal peritoneum morphology (MP:0009216)

  • abnormal thymocyte activation (MP:0003850)

  • decreased double-positive T cell number (MP:0005092)

  • decreased interleukin-4 secretion (MP:0008700)

  • increased B cell number (MP:0005014)

  • increased CD4-positive, alpha-beta T cell number (MP:0008074)

  • increased CD8-positive, alpha-beta T cell number (MP:0008078)

  • increased IgA level (MP:0002495)

  • increased IgG1 level (MP:0008499)

  • increased IgG2a level (MP:0008500)

  • increased IgG2b level (MP:0008501)

  • increased activated T cell number (MP:0001829)

  • increased anti-double stranded DNA antibody level (MP:0004762)

  • increased anti-nuclear antigen antibody level (MP:0004794)

  • increased anti-single stranded DNA antibody level (MP:0004771)

  • increased autoantibody level (MP:0003725)

  • increased bone mineral content (MP:0010123)

  • increased bone mineral density (MP:0000062)

  • increased bone mineralization (MP:0020080)

  • increased bone ossification (MP:0020039)

  • increased double-negative T cell number (MP:0005090)

  • increased interferon-gamma secretion (MP:0008566)

  • increased neutrophil cell number (MP:0000219)

  • increased single-positive T cell number (MP:0008082)

  • increased trabecular bone thickness (MP:0009347)

  • lymph node hyperplasia (MP:0008102)

  • osteoporosis (MP:0000066)

  • rheumatoid arthritis (MP:0003561)

  • spleen hyperplasia (MP:0000693)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman gp130遺伝子 cDNA, E. coli neo 遺伝子
    Research applicationImmunology and Inflammation Research
    covid19_onset
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp Med., 196, 979-990 (2002). Immunity, 12, 95-105 (2000).
    DepositorToshio Hirano (The University of Osaka)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data