RBRC01498

Information1

Image
BRC No.RBRC01498
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Camk2-mutPolg)1Bsi
Former Common nameBipolar Disorder Model Mouse
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Drs. Takaoki Kasahara and Tadafumi Kato at RIKEN BSI in 2001. The mutant POLG coding fragment including the CaMKII alpha promoter was injected into the pronuclei of C57BL/6J fertilized eggs.
Strain descriptionBipolar disorder, a mood disorder marked by alternating periods of manic and depressive episodes, affects approximately 1% of the global population. Mitochondrial dysfunction has been seen in patients with bipolar disorder. Moreover, patients with mitochondrial disorders sometimes display mood disorders. This transgenic mice express mouse mitochondrial DNA polymerase (POLG) having a point mutation D181A under the control of CaMKII alpha promoter. The mutant mice exhibited characteristic behavioral phenotypes in accordance with criteria for the validation as an animal model of mood disorder. This strain is useful to investigate the cause of bipolar disorder and to develop new mood stabilizers to treat bipolar disorder.
Colony maintenanceBackcross to C57BL/6 (hemizygote male x 57BL/6JJcl female)Don't use Tg female for breeding in order to prevent transmission of mutated mtDNA.
ReferencesMol. Psychiatry, 11, 577-593 (2006). 16619054

Health Report

Examination Date / Room / Rack2020/01/27Room:4-ARack:B
2019/11/25Room:4-ARack:B
2019/09/30Room:4-ARack:B
2019/07/29Room:4-ARack:B
2019/05/27Room:4-ARack:B
2019/03/25Room:4-ARack:B
2019/01/28Room:4-ARack:B
2018/11/26Room:4-ARack:B

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Polgpolymerase (DNA directed), gammaUNPolgmouse Camk2a promoter

Information2

Donor DNAmouse CaMKIIα promoter , mouse Polg (mitochondrial DNA polymerase γ) mutant cDNA, SV40 polyA
Research applicationCell Biology Research
Mouse Models for Human Disease
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Molecular Psychiatry, 11, 577-593 (2006).The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.
The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE when the RECIPIENT ordered the BIOLOGICAL RESOURCE before the publication of the paper indicated above.
DepositorTadafumi Kato (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Lab HP
Mouse of the Month May 2006

BRC mice in Publications

No Data