Strain Data Sheet


Strain Information

BRC No.RBRC01465
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6(Cg)-Cacna1g<tm1.3Ksak>/KsakRbrc
Former Common nameCa1G KO, C57BL/6-Cacna1g<-/+>
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Strain development
Strain descriptionCacna1g gene is a member of the low-voltage-activated calcium channel that plays a critcal role in calcium ion transport in nerve, muscle and endocrine cells. This conditional Cacna1g deficient mice were generated by crossing with telencephalin specific Cre transgenic mice.
Colony maintenance
ReferencesBiochem. Biophys. Res. Commun., 318, 665-672 (2004). 15144889
Eur. J. Neurosci., 13, 179-189 (2001). 11135016

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit11Cacna1g<tm1.3Ksak>targeted mutation 1.3, Kenji Skimura[a]1G, a1G, alpha-1G, Cav3.1d, mKIAA1123

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP11loxP

Ordering Information

Donor DNAPhage P1 loxP site, mouse Cacna1g genomic DNA
Research applicationCre/loxP system
Specific Term and Conditions・The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
・The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for 2 year after provided to the RIKEN BRC.
・Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
DepositorKenji Sakimura (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K.
Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.
Cell Rep 16(4) 994-1004(2016) 27425615

Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM.
CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.
Neuropharmacology 135 343-354(2018) 29578032

Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A.
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
Neuropharmacology 59(6) 380-7(2010) 20547167

Choi S, Yu E, Hwang E, Llinás RR.
Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain.
Proc Natl Acad Sci U S A 113(8) 2270-5(2016) 26858455

Choi S, Yu E, Lee S, Llinás RR.
Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness.
Proc Natl Acad Sci U S A 112(25) 7839-44(2015) 26056284