RBRC01465

Information1

Image
BRC No.RBRC01465
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Cacna1g-/+
Former Common nameCa1G KO
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
ReferencesEur. J. Neurosci., 13, 179-189 (2001). 11135016
Biochem. Biophys. Res. Commun., 318, 665-672 (2004). 15144889

Health Report

Examination Date / Room / Rack2008/08/04Room:3-3Rack:B
2008/06/09Room:3-3Rack:B
2008/04/08Room:3-3Rack:B
2008/04/07Room:3-3Rack:B
2008/02/04Room:3-3Rack:B
2007/12/03Room:3-3Rack:B
2007/10/01Room:3-3Rack:B
2007/08/06Room:3-3Rack:B

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit11Cacna1g<tm1.3Ksak>targeted mutation 1.3, Kenji Skimura

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP11loxP

Information2

Donor DNAPhage P1 loxP site, mouse Cacna1g genomic DNA
Research applicationCre/loxP system
Specific Term and Conditions・The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
・The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for 2 year after provided to the RIKEN BRC.
・Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
DepositorKenji Sakimura (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K.
Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.
Cell Rep 16(4) 994-1004(2016) 27425615

Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM.
CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.
Neuropharmacology (2018) 29578032

Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A.
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
Neuropharmacology 59(6) 380-7(2010) 20547167

Choi S, Yu E, Hwang E, Llinás RR.
Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain.
Proc. Natl. Acad. Sci. U.S.A. 113(8) 2270-2275. (2015) 26858455

Choi S, Yu E, Lee S, Llinás RR.
Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness.
Proc. Natl. Acad. Sci. U.S.A. 112(25) 7839-7844(2015) 26056284