RBRC01445

Information1

Image
BRC No.RBRC01445
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameDDY-Dao<G181R>/ConnRbrc
Former Common nameddY/DAO<-> mice
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [c/c]
Strain developmentSpontaneous mutation arose in the ddY closed colony. Developed by Dr. Ryuichi Konno, Dokkyo University.
Strain descriptionThis mutant mice have a missense mutation (Gly181Arg) in DAO gene. The mice with this mutant allele lack the D-amino acid oxidase activity. The levels of D-serine in the cerebellum and rostral brain of mutant mice are higher than those of normal (Dao1+/+) mice. The mutant mice display a decrease of stereotypy and ataxia induced by NMDA receptor antagonists. This strain is useful for study of schizophrenia.
Colony maintenanceSibling Mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile.
ReferencesArch Toxicol., 74, 473-479 (2000). 11097385
Am. J. Physiol. Endocrinol. Metab., 287, E160-E165 (2004). 15026304
Biochim. Biophys. Acta., 1335, 173-181 (1997). 9133654
Synapse, 50, 130-136 (2003). 12923815
J. Chromatogr. B, 757, 119-125 (2001). 11419736
Brain Res., 1033, 210-215 (2005). 15694926
Lab. Anim. Sci., 38, 292-295 (1988). 2900911
Genetics, 103, 277-285 (1983). 6131852
Biochim. Biophys. Acta., 967, 382-390 (1988). 2904279
Metabolism, 37, 1139-1142 (1988). 2904113
J. Nutr., 114, 1617-1621 (1984). 6147398
Anal. Biochem., 298, 253-258 (2001). 11700980
Biochim. Biophys. Acta., 1139, 315-318 (1992). 1355365
Int. J. Biochem., 23, 1301-1305 (1991). 1686595
Neurosci. Lett., 297, 25-28 (2001). 11114476
Amino Acids, 10, 133-143 (1996). 24178475
Am. J. Physiol., 265, G699-G703 (1993). 7901999

Health Report

Examination Date / Room / Rack2014/11/17Room:4-BRack:D
2014/09/16Room:4-BRack:D
2014/07/30Room:4-BRack:D
2014/07/28Room:4-BRack:D
2014/07/14Room:4-BRack:D
2014/05/19Room:4-BRack:D
2014/03/24Room:4-BRack:D
2014/01/20Room:4-BRack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Dao1D-amino acid oxidase 15Dao1<G181R>

Information2

Donor DNA
Research applicationCell Biology Research
Genetics Research
Neurobiology Research
Toxicology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
DepositorRyuichi, Konno (Dokkyo Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data