RBRC01420

Information1

Image
BRC No.RBRC01420
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Irf7<tm1Ttg>/TtgRbrc
Former Common nameIRF-7-KO, IRF7, IRF-7 knockout mice, C57BL/6J
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6J
Appearanceblack [a/a]
Strain developmentDeveloped by Kenya Honda and Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo in 2001. The knockout construct was electroporated into E14 ES cells derived from 129P2/OlaHsd. C57BL/6 semicongenic strain.
Strain descriptionIRF7 knockout mice. Exon 2 and 3 of Irf7 gene were replaced with a PGK-beta-geo cassette. Homozygous mutant mice are vulnerable to viral infection with a decreased serum interferon level.
Colony maintenanceHomozygote x Homozygote
ReferencesNature, 434, 772-777 (2005). 15800576

Health Report

Examination Date / Room / Rack2020/06/15Room:4-BRack:L
2020/06/08Room:4-BRack:L
2020/03/30Room:4-BRack:L
2020/01/27Room:4-BRack:L
2019/11/25Room:4-BRack:L
2019/09/30Room:4-BRack:L
2019/07/29Room:4-BRack:L
2019/05/27Room:4-BRack:L

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Irf7interferon regulatory factor 77Irf7<tm1Ttg>targeted mutation 1, Tadatsugu Taniguchi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)7mouse phosphoglycerate kinase promoter (PGK promoter)

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)7

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli beta-geo gene (E. coli neo, E. coli lacZ), mouse IRF-7 genomic DNA
Research applicationFluorescent Proteins/lacZ System
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
DepositorTadatsugu Taniguchi (The University of Tokyo)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Genotyping protocol -PCR-
Mouse of the Month May 2005
Genetic Background

BRC mice in Publications

Wang XA, Zhang R, Zhang S, Deng S, Jiang D, Zhong J, Yang L, Wang T, Hong S, Guo S, She ZG, Zhang XD, Li H.
Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.
Am. J. Physiol. Endocrinol. Metab. 305(4) E485-95(2013) 23695216

Temizoz B, Kuroda E, Ohata K, Jonai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.
TLR9 and STING agonists synergistically induce innate and adaptive type II IFN.
Eur. J. Immunol. (2014) 25529558

Beattie L, Phillips R, Brown N, Owens BM, Chauhan N, Dalton JE, Kaye PM.
Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver.
Infect. Immun. 79(3) 1057-66(2011) 21149596

Prantner D, Sikes JD, Hennings L, Savenka AV, Basnakian AG, Nagarajan UM.
IRF3 protects from uterine horn pathology during Chlamydia muridarum genital infection in mice.
Infect. Immun. (2011) 21788382

Salem M, Mony JT, Lobner M, Khorooshi R, Owens T.
Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice.
J Neuroinflammation 8 181(2011) 22196084

Khorooshi R, Owens T.
Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system.
J. Immunol. 185(2) 1258-64(2010) 20562259

Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR.
Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.
J. Immunol. 178(11) 6876-85(2007) 17513736

Li W, Hofer MJ, Jung SR, Lim SL, Campbell IL.
IRF7-DEPENDENT, TYPE I INTERFERON PRODUCTION INDUCES LETHAL IMMUNE-MEDIATED DISEASE IN STAT1 KO MICE INFECTED WITH LCMV.
J. Virol. (2014) 24760883

Zhou S, Cerny AM, Fitzgerald KA, Kurt-Jones EA, Finberg RW.
Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
J. Virol. 86(20) 11254-65(2012) 22875973

Christensen JE, Fenger C, Issazadeh-Navikas S, Krug A, Liljestr m P, Goriely S, Paludan SR, Finsen B, Christensen JP, Thomsen AR.
Differential impact of interferon regulatory factor 7 in the initiation of the type I interferon response in the LCMV infected CNS versus the periphery.
J. Virol. (2012) 22514347

Kinpara S, Hasegawa A, Utsunomiya A, Nishitsuji H, Furukawa H, Masuda T, Kannagi M.
Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in vitro and in vivo by type I interferon.
J. Virol. 83(10) 1167893(2009) 19264779

Phillips R, Svensson M, Aziz N, Maroof A, Brown N, Beattie L, Signoret N, Kaye PM.
Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7.
PLoS Pathog. 6(3) e1000813(2010) 20300600

Puthia M, Ambite I, Cafaro C, Butler D, Huang Y, Lutay N, Rydström G, Gullstrand B, Swaminathan B, Nadeem A, Nilsson B, Svanborg C.
IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.
Sci Transl Med 8(336) 336ra59. (2016) 27122612

Giordano G, van den Br le S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F.
Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.
Toxicol. Sci. 116(2) 682-92(2010) 20513754

Li W, Hofer MJ, No on AL, Manders P, Campbell IL.
Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice.
Virology 439(2) 152-62(2013) 23490048