Strain Data Sheet

RBRC01395

Strain Information

Image
BRC No.RBRC01395
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(tetO-AML1/MTG8)1/Rbrc
Former Common nameTOAM8G mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Kiwamu Akagi at 1999. The human AML1-MTG8 chimeric gene was injected into C57BL/6 fertilized eggs.
Strain descriptionThis transgenic mice express a AML1-MTG8 chimeric gene that is activated by the TetR-transactivator. This strain is useful for model mouse of leukemia.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
CBFA2T1H CBFA2T1 identified gene homolog (human)UNCBFA2T1H
RUNX1 runt related transcription factor 1 (human)UNRUNX1

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • increased chronic lymphocytic leukemia incidence (MP:0010337)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman CMV mini promoter with heptamerized tet-operators upstream, rabbit beta-globin poly A, human AML1-MTG8 cDNA
    Research applicationTet system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in
    any publications resulted by the use of the BIOLOGICAL RESOURCE during the
    first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
    DepositorKiwamu AKAGI (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data