Strain Data Sheet


Strain Information

BRC No.RBRC01342
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Emx1-cre)1Ito/ItoRbrc
Former Common nameEmx1-Cre Tg1
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Takuji Iwasato and Shigeyoshi Itohara, RIKEN Brain Science Institute. The transgene was injected into the pronuclei of C57BL/6 fertilized eggs. C57BL/6 background.
Strain descriptionEmx1-Cre transgenitc mice, containing a transcriptional unit of a dorsal telencephalon specific promoter (Emx1 promoter) and Cre recombinase gene. Line 1 (RBRC01342), Line 2 (RBRC01343) and Line 3 (RBRC01344). The most suitable cre driver strain is Emx1-cre delta neo knock-in mice (RBRC01345) (no ectopic cre expression is detected).
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
ReferencesGenesis, 38, 130-138 (2004). 15048810

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
crePhage P1 Cre recombinaseUNcremouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, SV40 poly A

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
nlsSV40 large T antigen nuclear localization signal (NLS)UNnls

Ordering Information

Donor DNAmouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, Simian virus 40 Large T antigen nuclear localization signal (NLS), phage P1 Cre recombinase, SV40 poly A
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 38, 130-138 (2004).
DepositorShigeyoshi Itohara (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-
Mouse of the Month June 2006

BRC mice in Publications

Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG.
Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
Cell Rep 30(6) 1964-1981.e3(2020) 32049024

Chen CM, Wang HY, You LR, Shang RL, Liu FC.
Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.
Dev Dyn 239(6) 1797-806(2010) 20503375

Buth JE, Dyevich CE, Rubin A, Wang C, Gao L, Marks T, Harrison MR, Kong JH, Ross ME, Novitch BG, Pearson CA.
Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance.
EMBO Rep (2024) 38600346