Strain Data Sheet

RBRC01342

Strain Information

Image
BRC No.RBRC01342
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Emx1-cre)1Ito/ItoRbrc
Former Common nameEmx1-Cre Tg1
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Takuji Iwasato and Shigeyoshi Itohara, RIKEN Brain Science Institute. The transgene was injected into the pronuclei of C57BL/6 fertilized eggs. C57BL/6 background.
Strain descriptionEmx1-Cre transgenitc mice, containing a transcriptional unit of a dorsal telencephalon specific promoter (Emx1 promoter) and Cre recombinase gene. Line 1 (RBRC01342), Line 2 (RBRC01343) and Line 3 (RBRC01344). The most suitable cre driver strain is Emx1-cre delta neo knock-in mice (RBRC01345) (no ectopic cre expression is detected).
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
References
Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice.
Iwasato T, Nomura R, Ando R, Ikeda T, Tanaka M, Itohara S
Genesis, 38, 130-138 (2004). 15048810

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
cre Phage P1 Cre recombinaseUNcre mouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, SV40 poly A
nls SV40 large T antigen nuclear localization signal (NLS)UNnls

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • no abnormal phenotype detected (MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, Simian virus 40 Large T antigen nuclear localization signal (NLS), phage P1 Cre recombinase, SV40 poly A
    Research applicationCre/loxP system
    Cre driver
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 38, 130-138 (2004).
    DepositorShigeyoshi Itohara (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month June 2006

    BRC mice in Publications

    Buth JE, Dyevich CE, Rubin A, Wang C, Gao L, Marks T, Harrison MR, Kong JH, Ross ME, Novitch BG, Pearson CA.
    Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance.
    EMBO Rep (2024) 38600346
    Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG.
    Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
    Cell Rep 30(6) 1964-1981.e3(2020) 32049024
    Chen CM, Wang HY, You LR, Shang RL, Liu FC.
    Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.
    Dev Dyn 239(6) 1797-806(2010) 20503375