BRC No.RBRC01293
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Psap<tm1Juma>/Rbrc
Former Common nameSaposin D mutant mouse
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Dr. Junko Matsuda, the University of Tokushima Graduate School and Dr. Kunihiko Suzuki, University of North Carolina at 2004.
Strain descriptionHomozygous mutant mice exhibit renal tubular degeneration around 2 months, and a cerebellar Purkinje cell degeneration around 4 months with accumulation of hydroxy fatty acid-containing ceramide. Average life sopan is 10-15 months.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
ReferencesHum. Mol. Genet., 13, 2709-2723 (2004). 15345707

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Psapprosaposin10Psap<tm1Jmat>targeted mutation 1, Junko Matsuda

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP10loxP


Donor DNAPhage P1 loxP site, mouse prosaposin genomic DNA
Research applicationCre/loxP system
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 13, 2709-2723 (2004).
DepositorJunko Matsuda (Tokushima University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data