Strain Data Sheet
RBRC01262
Information1 | |
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| Image |  |
| BRC No. | RBRC01262 |
| Type | Spontaneous Mutation |
| Species | Mus musculus |
| Strain name | C3.Cg-Mitf<mi-bw>/Rbrc |
| Former Common name | Black-eyed white, Mitf<mi-bw> mutant mouse |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | black eyed white [A/A B/B C/C mi<bw>/mi<bw>] |
| Strain development | The original mutant strain, C3HBSt carrying Mitf<mi-bw> allele was provided by Dr. Walter C. Quevedo Jr., Brown University to Tohoku University. The originals were backcrossed to C57BL/6J strain for 13 times. After several years, they were backcrossed to C3H/He strain because the homozygous mice became difficult to breed. |
| Strain description | C3;B6-Mitf<mi-bw>. The Mitf, microphthalmia-associated transcription factor plays a critical role in the development of melanocytes, mast cells, osteoclasts and pigmented epithelium. Homozygous mice for the Mitf<mi-bw> mutation display a white coat with black eyes. In this allele, a L1 element was inserted into intron 3. This strain is useful as an animal model for Waardenburg syndrome type 2 (WS2) |
| Colony maintenance | Sibling Mating (Homozygote x Homozygote)Homozygote shows white coat color with black eyes. |
| References | Hum. Mol. Genet., 8, 1431-1441 (1999). 10400990 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Mitfmicrophthalmia-associated transcription factor6Mitf<mi-bw>black eyed whiteblack eyed white, mi, wh |
Information2 | |
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| Donor DNA | |
| Research application | Genetics Research Mouse Models for Human Disease |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 8, 1431-1441 (1999). |
| Depositor | Hiroaki Yamamoto (Tohoku University) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Mouse of the Month Dec 2006 Necessary documents for ordering: |
BRC mice in Publications |
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Ohba K, Takeda K, Yamamoto H, Shibahara S. Microphthalmia-associated transcription factor is expressed in projection neurons of the mouse olfactory bulb. Genes Cells 20(12) 1088-102(2015) 26522736 |