Strain Data Sheet

RBRC01261

Strain Information

Image
BRC No.RBRC01261
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameICR.Cg-Atp7a<Mo-Tohm>/TohmRbrc
Former Common nameMottled Tohoku
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Phenotypic and genetic characterization of the Atp7a(Mo-Tohm) mottled mouse: a new murine model of Menkes disease.
Mototani Y, Miyoshi I, Okamura T, Moriya T, Meng Y, Yuan Pei X, Kameo S, Kasai N
Genomics, 87, 191-199 (2006). 16338116

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atp7a
MGI:99400		ATPase, Cu++ transporting, alpha polypeptideXAtp7a<Mo-Tohm>
MGI:3588774		mottled Tohoku
  • Menkes disease(DisGeNET, MedGEN)

  • occipital horn syndrome(DisGeNET, MedGEN)

  • X-linked distal spinal muscular atrophy type 3(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal Ammon gyrus morphology (MP:0000815)

  • abnormal Purkinje cell morphology (MP:0000877)

  • abnormal aorta elastic fiber morphology (MP:0003211)

  • abnormal cerebellar granule layer morphology (MP:0000886)

  • abnormal cerebral cortex morphology (MP:0000788)
    • more 14 phenotypes
  • abnormal copper level (MP:0003952)

  • abnormal motor capabilities/coordination/movement (MP:0002066)

  • abnormal visceral yolk sac morphology (MP:0001718)

  • abnormal vitelline vascular remodeling (MP:0004076)

  • abnormal vitelline vasculature morphology (MP:0003229)

  • decreased brain copper level (MP:0011215)

  • embryonic lethality during organogenesis, complete penetrance (MP:0011098)

  • hemorrhage (MP:0001914)

  • increased apoptosis (MP:0006042)

  • increased brain apoptosis (MP:0014178)

  • mortality/aging (MP:0010768)

  • mottled coat (MP:0000421)

  • postnatal growth retardation (MP:0001732)

  • postnatal lethality, incomplete penetrance (MP:0011086)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorNoriyuki Kasai (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data