Strain Data Sheet

RBRC01235

Information1

Image
BRC No.RBRC01235
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameSTOCK Ptpro<tm1Shs>/Rbrc
Former Common nameGlepp1-KO, Glepp1 Knockout mice
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack (a/a B/B C/C)
Strain developmentDeveloped by Dr. Takuya Tomemori at Tokyo Metropolitan Institute of Gerontology in 2001.
Strain descriptionThe Glepp1 (Ptpro) gene is a receptor tyrosine phsophatase that is present on the surface of the glomerular podocyte and plays in regulating podocyte structure and function. Homozygous mutant mice are viable and fertile.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
References

Health Report

Examination Date / Room / Racknull

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ptproprotein tyrosine phosphatase, receptor type, O6Ptpro<tm1Shs>targeted mutation 1, Takuji ShirasawaGlepp1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)6neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Glepp1 genomic DNA[update Oct., 20, 2014]
Research applicationCell Biology Research
Cre/loxP system
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
DepositorTakuji Shirasawa (Tokyo Metropolitan Institute of Gerontology)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese), Lab HP (English)
Genotyping protocol -PCR-

BRC mice in Publications

Yu, Yang.
Regulation of retinal axonal projections by the R3 receptor-like protein tyrosine phosphatase subfamily in mice.
SOKENDAI (The Graduate University for Advanced Studies) (2018)