Strain Data Sheet

RBRC01235

update : 2023-09-20

Information1
Image
BRC No.	RBRC01235
Type	Targeted Mutation
Species	Mus musculus
Strain name	STOCK Ptpro<tm1Shs>/Rbrc
Former Common name	Glepp1-KO, Glepp1 Knockout mice
H-2 Haplotype
ES Cell line
Background strain
Appearance	black (a/a B/B C/C)
Strain development	Developed by Dr. Takuya Tomemori at Tokyo Metropolitan Institute of Gerontology in 2001.
Strain description	The Glepp1 (Ptpro) gene is a receptor tyrosine phsophatase that is present on the surface of the glomerular podocyte and plays in regulating podocyte structure and function. Homozygous mutant mice are viable and fertile.
Colony maintenance	Sibling Mating (Homozygote x Homozygote)
References

Health Report
Examination Date / Room / Rack

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Ptproprotein tyrosine phosphatase, receptor type, O6Ptpro<tm1Shs>targeted mutation 1, Takuji ShirasawaGlepp1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP6loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP6loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)6neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Gene info

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

Ptproprotein tyrosine phosphatase, receptor type, O6Ptpro<tm1Shs>targeted mutation 1, Takuji ShirasawaGlepp1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

neoneomycin resistance gene (E. coli)6neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Information2
Donor DNA	phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Glepp1 genomic DNA[update Oct., 20, 2014]
Research application	Cell Biology Research Cre/loxP system
Specific Term and Conditions	The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Depositor	Takuji Shirasawa (Tokyo Metropolitan Institute of Gerontology)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English) Lab HP (Japanese), Lab HP (English) Genotyping protocol -PCR-

BRC mice in Publications

Yu, Yang. Regulation of retinal axonal projections by the R3 receptor-like protein tyrosine phosphatase subfamily in mice. SOKENDAI (The Graduate University for Advanced Studies) (2018)