RBRC01229

Information1

Image
BRC No.RBRC01229
TypeTargeted Mutation and Chromosomal Aberration and F2 HybridCartagena
SpeciesMus musculus
Strain nameB6;129-Foxh1<tm1.1Hmd>/HmdRbrc
Former Common nameB6;129-FoxH1+/-, FAST+/-, B6;129-FoxH1tm1Hh(B6;129-FoxH1+/-,FAST+/- ) knockout mice
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Masamichi Yamamoto and Hiroshi Hamada at Osaka University in 2001. Foxh1<tm1.1Hmd> mutant mice were generated from Foxh1<tm1Hmd> mutant mice by crossing with cre-expressing line, Tg(ACTB-cre)Miya mice strain.
Strain descriptionB6;129-Foxh1<tm1.1Hmd>. The transcription factor Foxh1 (horkhead box H1) mediates signaling by transforming growth factor-β, Activin, and Nodal. Foxh1 null deficient mice are perinatal lethal. The embryos of Foxh1 deficient mice exhibit various patterning defects by the loss of Nodal signaling. This mice are useful for the study of Foxh1 gene in vivo.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6Cr)Homozygous mutant mice are perinatal lethal.
ReferencesGenes Dev., 15, 1242-1256 (2001). 11358868

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
FoxH1forkhead box H115FoxH1<tm1.1Hmd>targeted mutation 1.1, Hiroshi Hamada

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP15loxP

Information2

Donor DNAphage P1 loxP, mouse FoxH1 genomic DNA
Research applicationDevelopmental Biology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on
use of it from the DEPOSITOR.
DepositorHiroshi Hamada (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data