RBRC01188

Information1

Image
BRC No.RBRC01188
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak/TanakRbrc
Former Common namet(7;11)AML NUP98-HOXA9 transgenic (Tg) mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Kakuro Nakamura, NIH in 1996. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J over 10 times.
Strain descriptionB6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak. This transgenic mice express the chimeric NUP98-HOXA9 gene in the myeloid lineage. About 20% of mice with this transgene exhibit myeloproliferative disorder and acute myeloid leukemia (AML).
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
ReferencesBlood, 105, 784-793 (2005). 15454493

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
CTSGCathepsin G (human)UNCTSG

Gene symbolGene nameChr.Allele symbolAllele namePromoter
HOXA9homeo box A9 (human)UNHOXA9

Gene symbolGene nameChr.Allele symbolAllele namePromoter
NUP98nucleoporin 98 (human)UNNUP98human Cathepsin G promoter

Information2

Donor DNAhuman Cathepsin G genomic DNA, human NUP98-HOXA9 cDNA
Research applicationCancer Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
DepositorTakuro Nakamura (Japanese Foundation for Cancer Research)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Mar 2006

BRC mice in Publications

Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore MA, Sato H, Wong RW.
RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.
Cell Cycle 10(9) 1456-67(2011) 21467841