Strain Data Sheet

RBRC01171

Strain Information

Image
BRC No.RBRC01171
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.Cg-Hivep2<tm1Sis>/Rbrc
Former Common nameSchnurri-2(Shn-2) Knockout mice -BALB/c
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainBALB/cAJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Murine Schnurri-2 is required for positive selection of thymocytes.
Takagi T, Harada J, Ishii S
Nat. Immunol., 2, 1048-1053 (2001). 11668343

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hivep2human immunodeficiency virus type I enhancer binding protein 210Hivep2targeted mutation 1, Shunsuke Ishii
  • intellectual disability, autosomal dominant 43(MedGEN)
  • neoneomycin resistance gene (E. coli)10mouse phosphoglycerate kinase promoter (PGK promoter)
  • intellectual disability, autosomal dominant 43(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • CNS inflammation(MP:0006082)

  • abnormal T-helper 2 cell morphology(MP:0002434)

  • abnormal astrocyte physiology(MP:0008916)

  • abnormal brain wave pattern(MP:0004994)

  • abnormal cerebellar granule cell morphology(MP:0004098)
  • more 23 phenotypes
  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal dentate gyrus morphology(MP:0000812)

  • abnormal immune system cell morphology(MP:0000716)

  • abnormal nest building behavior(MP:0001447)

  • abnormal positive T cell selection(MP:0004919)

  • abnormal response to social novelty(MP:0020395)

  • abnormal spatial working memory(MP:0008428)

  • abnormal synaptic transmission(MP:0003635)

  • abnormal thymus cortex morphology(MP:0002371)

  • abnormal thymus lobule morphology(MP:0002367)

  • abnormal thymus medulla morphology(MP:0002375)

  • abnormal visual cortex morphology(MP:0000805)

  • anhedonia(MP:0009710)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased body weight(MP:0001262)

  • decreased neuron number(MP:0008948)

  • decreased oligodendrocyte number(MP:0009808)

  • decreased prepulse inhibition(MP:0009142)

  • decreased single-positive T cell number(MP:0008083)

  • enlarged thymus cortex(MP:0013593)

  • hyperactivity(MP:0001399)

  • increased thermal nociceptive threshold(MP:0001973)

  • thin cerebral cortex(MP:0006254)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Schnurri-2 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 2, 1048-1053 (2001). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShunsuke Ishii (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.
    Neuropsychopharmacology 38(8) 1409-25(2013) 23389689