Strain Information | |
---|---|
Image | |
BRC No. | RBRC01171 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C.Cg-Hivep2<tm1Sis>/Rbrc |
Former Common name | Schnurri-2(Shn-2) Knockout mice -BALB/c |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | BALB/cAJcl |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Murine Schnurri-2 is required for positive selection of thymocytes. Takagi T, Harada J, Ishii S Nat. Immunol., 2, 1048-1053 (2001). 11668343 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |||||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Hivep2 | human immunodeficiency virus type I enhancer binding protein 2 | 10 | Hivep2 | targeted mutation 1, Shunsuke Ishii | |||
neo | neomycin resistance gene (E. coli) | 10 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
---|---|
Annotation by Mammalian phenotyhpe ontology | more 23 phenotypes |
Detailed phenotype data |
Ordering Information | |
---|---|
Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Schnurri-2 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 2, 1048-1053 (2001). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Shunsuke Ishii (RIKEN) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38(8) 1409-25(2013) 23389689 |