RBRC01170
Information1 | |
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| Image | |
| BRC No. | RBRC01170 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.Cg-Hivep2<tm1Sis>/Rbrc |
| Former Common name | Shn-2 KO B6, Schnurri-2(Shn-2) Knockout mice -B6 |
| H-2 Haplotype | |
| ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
| Background strain | C57BL/6J |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Nat. Immunol., 2, 1048-1053 (2001). 11668343 |
Health Report | |
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| Examination Date / Room / Rack | No Data |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Hivep2human immunodeficiency virus type I enhancer binding protein 210Hivep2<tm1Sis>targeted mutation 1, Shunsuke IshiiSchnurri-2, MIBP1, Shn-2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)10neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Information2 | |
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| Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Schnurri-2 genomic DNA |
| Research application | Immunology and Inflammation Research |
| Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature Immunology, 2, 1048-1053 (2001).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 1. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. 2. The RECIPIENT must inform the DEPOSITOR the research project using the BIOLOGICAL RESOURCE and must obtain a prior permission from the DEPOSITOR to avoid the conflict of interest with the DEPOSITOR. |
| Depositor | Shunsuke Ishii (RIKEN) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
| Additional Info. | Genotyping protocol -PCR- Approval form ( Japanese / English Lab HP |
BRC mice in Publications |
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Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38(8) 1409-25(2013) 23389689 |