Strain Data Sheet

RBRC01154

Strain Information

Image
BRC No.RBRC01154
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Six3-cre)69Frty
Former Common nameTgN(Six3 Cre)69Frt; Six3Cre#69
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Yasuhide Furuta, University of Texas, M.D. Anderson Cancer Center. The Six3-cre transgene fragment was injected into the pronuclei of B6D2F2 fertilized eggs. The mice were crossed to C57BL/6 (N5 times).
Strain descriptionTransgenic mice expressing Cre recombinase in a central region of the developing retina and widely in the ventral forebrain. Useful for tissue-specific gene activation/inactivation approaches. In particular, consequences of gene activation/inactivation in Cre-expressing cells within the retina can be assessed in direct comparisons to the surrounding non-Cre-expressing cells in an animal. Line 69 (RBRC01154), Line 22 (RBRC01153).
Colony maintenanceCarrier x Carrier
References
Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice.
Furuta Y, Lagutin O, Hogan B L, Oliver G C
Genesis, 26, 130-132 (2000). 10686607

Health Report

Examination Date / Room / Rack2025/09/01Room:3-ARack:FSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GH Growth hormone polyA (Bovine)UNGH
cre Phage P1 Cre recombinaseUNcre
MGI:3574771		mouse Six3 promoter
nls SV40 large T antigen nuclear localization signal (NLS)UNnls

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • normal phenotype (MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse six3 genomic DNA, SV40-T-derived nuclear localization signal (NLS), phage P1 Cre recombinase, bovine Growth Hormone polyA signal
    Research applicationCell Biology Research
    Cre/loxP system
    Genetics Research
    Cre driver
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 26, 130-132 (2000).
    DepositorYasuhide Furuta (The University of Texas M. D. Anderson Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month June 2006

    BRC mice in Publications

    No Data