RBRC01144

Information1

Image
BRC No.RBRC01144
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S7-Heyl<tm1Kkb>/YsaRbrc
Former Common namehairy and enhancer of split-related 3 Knock in (LacZ)
H-2 Haplotype
ES Cell line
Background strainC57BL/6NJcl
Appearanceblack [a/a , B/B , C/C]
Strain developmentB6;129S7-Heyl<tm1Kkb>. The Heyl gene is a member of the hairy and enhancer of split related family of bHLH transcription factors, play important roles in mediating the Notch signaling pathway. It is suggested that the Heyl gene has a role of the differentiation of retina. This strain is useful for elucidation of the Notch-signaling pathway mechanism.
Strain descriptionDeveloped by Drs. H. Kokubo and R.L. Johnson at University of Texas M.D. Anderson Cancer Center in 1999. Combined loxP site and lacZ-Neo cassette was transferred into Heyl gene.
Colony maintenanceSibling mating.Homozygous mutant mice are fertile and display no obvious defects.
References

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Heylhairy and enhancer of split-related 34Heyl<tm1Kkb>targeted mutation 1, Hiroki Kokubo

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)4

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP4loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP4loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)4

Information2

Donor DNAmouse hairy and enhancer of split-related 3 genomic DNA, E. coli lacZ, E. coli neo, phage P1 loxP
Research application
Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorYumiko Saga (National Institute of Genetics)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Saga Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data