Strain Information | |
---|---|
Image | ![]() |
BRC No. | RBRC01081 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.129S-Drd2<tm1Mok> |
Former Common name | D2R KO, B6-D2R KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | |
Appearance | black |
Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences (Medical Institute of Bioregulation, Kyushu University). |
Strain description | D2R (Drd2) gene knockout mice. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M Genes Cells, 1, 253-268 (1996). 9140068Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior. Nakamura T, Sato A, Kitsukawa T, Momiyama T, Yamamori T, Sasaoka T Front Integr Neurosci., 8, 56 (2014). 25076876Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity. Nakamura T, Sato A, Kitsukawa T, Sasaoka T, Yamamori T Front Cell Dev Biol., 3, 38 (2015). 26137459 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |||||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Drd2 MGI:94924 | dopamine receptor D2 | 9 | Drd2<tm1Mok> MGI:3576789 | targeted mutation 1, Motoya Katsuki | |||
neo | neomycin resistance gene (E. coli) | 9 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
---|---|
Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
---|---|
Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse dopamine receptor2 genomic DNA |
Research application | Neurobiology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells. 1, 253-68, (1996). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K. Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. Mol Psychiatry 22(8) 1205-1222(2017) 27922607 |
Wakabayashi C, Numakawa T, Ooshima Y, Hattori K, Kunugi H. Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet. Psychopharmacology (Berl) 232(24) 4393-400(2015) 26359228 |