RBRC01080

Information1

Image
BRC No.RBRC01080
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Drd1a<tm1Mok>
Former Common nameD1R KO, B6-D1R KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD1R (Ded1a) gene knockout mice.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesFront Integr Neurosci., 8, 56 (2014). 25076876
Front Cell Dev Biol., 3, 38 (2015). 26137459
J. Neurosci., 28(50):13390-13400 (2008). 19074012

Health Report

Examination Date / Room / Rack2014/08/04Room:3-1Rack:D
2014/06/02Room:3-1Rack:D
2014/05/12Room:3-1Rack:D
2014/03/10Room:2-検Rack:G
2014/01/14Room:2-検Rack:G
2013/11/11Room:2-検Rack:G
2013/09/09Room:2-検Rack:G
2013/07/08Room:2-検Rack:G

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Drd1dopamine receptor D1A13Drd1<tm1Mok>targeted mutation 1, Motoya Katsuki

Gene symbolGene nameChr.Allele symbolAllele namePromoter
EcogptE.coli xanthine phosphoribosyltransferase13Ecogptmouse phosphoglycerate kinase promoter (PGK promoter)

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)13herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase(Ecogpt), herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse dopamine receptor1 genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neuroscience, 28(50), 13390-13400 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorToshikuni Sasaoka (Niigata University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Oct 2009

BRC mice in Publications

Nguyen CL, Tran AH, Matsumoto J, Hori E, Uwano T, Ono T, Nishijo H.
Hippocampal place cell responses to distal and proximal cue manipulations in dopamine D2 receptor-knockout mice.
Brain Res. (2014) 24747614

Nagatomo K, Suga S, Saitoh M, Kogawa M, Kobayashi K, Yamamoto Y, Yamada K.
Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse.
Front Neuroanat 11 3(2017) 28203148

Hu Z, Oh EH, Chung YB, Hong JT, Oh KW.
Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration.
Korean J. Physiol. Pharmacol. 19(2) 89-97(2015) 25729269