RBRC01059

Information1

Image
BRC No.RBRC01059
TypeInbred
SpeciesMus musculus
Strain nameNC
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti brown [A/A b/b C/C D/D S/S]
Strain developmentDeveloped by Dr. Kyoji Kondo at Nagoya University, School of Agriculture. Derived from a cinnamon coat color colony of Japanese fancy mice (Nishiki-Nezumi).
Strain descriptionNC/Nga mice were originated from Japanese fancy mice (Nishiki-Nezumi) and were established as a inbred strain in 1955. NC/Nga mice develop skin lesions similar to atopic dermatitis when kept under conventional environment, but not under specific pathogen -free environment as specific pathogen-free animals. They also show a high susceptibility to X-irradiation and anaphylactic shock from ovalbumin. Developed by Dr. Kyoji Kondo at Nagoya University.
Colony maintenanceSibling Mating
ReferencesJIkken Doubutsu, 6, 107-112 (1957).

Health Report

Examination Date / Room / Rack2019/02/04Room:3-5Rack:C
2018/12/03Room:3-5Rack:C
2018/10/23Room:3-5Rack:C
2018/10/23Room:3-5Rack:C
2018/10/01Room:3-5Rack:C
2018/08/13Room:3-5Rack:C
2018/08/06Room:3-5Rack:C
2018/06/04Room:3-5Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Derm1dermititis 19Derm1NC/Nga

Information2

Donor DNA
Research applicationDermatology Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorTakao Namikawa (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

F Zhuo, MAS Abourehab, Z Hussain.
Hyaluronic Acid Decorated Tacrolimus-Loaded Nanoparticles: Efficient Approach to Maximize Dermal Targeting and Anti-dermatitis Efficacy.
Carbohydr. Polym. (2018) 30007638

Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E, Buang F, Sahudin S.
Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: An ex vivo and in vivo study using an NC/Nga mouse model.
Int J Pharm (2013) 23337632

Hussain Z, Katas H, Amin MC, Kumulosasi E, Sahudin S.
Antidermatitic perspective of hydrocortisone as chitosan nanocarriers: An ex vivo and in vivo assessment using an NC/Nga mouse model.
J Pharm Sci (2013) 23303620

Knitlova J, Hajkova V, Voska L, Elsterova J, Obrova B, Melkova Z.
Development of Eczema Vaccinatum in Atopic Mouse Models and Efficacy of MVA Vaccination against Lethal Poxviral Infection.
PLoS ONE 9(12) e114374 e114374(2014) 25486419

Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E.
Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs.
PLoS ONE 9(11) e113143 e113143(2014) 25396426

Yang Z, Liu M, Wang W, Wang Y, Cao B, Gao Y, Chen H, Li T.
Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation.
Sci Rep 7(1) 7918(2017) 28801611