|Former Common name|
|ES Cell line|
|Appearance||agouti brown [A/A b/b C/C D/D S/S]|
|Strain development||Developed by Dr. Kyoji Kondo at Nagoya University, School of Agriculture. Derived from a cinnamon coat color colony of Japanese fancy mice (Nishiki-Nezumi).|
|Strain description||NC/Nga mice were originated from Japanese fancy mice (Nishiki-Nezumi) and were established as a inbred strain in 1955. NC/Nga mice develop skin lesions similar to atopic dermatitis when kept under conventional environment, but not under specific pathogen -free environment as specific pathogen-free animals. They also show a high susceptibility to X-irradiation and anaphylactic shock from ovalbumin. Developed by Dr. Kyoji Kondo at Nagoya University.|
|Colony maintenance||Sibling Mating|
|References||JIkken Doubutsu, 6, 107-112 (1957).|
|Examination Date / Room / Rack||2022/05/31Room:4-BRack:J|
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
|Research application||Dermatology Research|
|Specific Term and Conditions||No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)|
|Depositor||Takao Namikawa (Nagoya University)|
|Strain Status||Live mice|
|Strain Availability||Cryopreserved embryos (within 1 month)|
Live mouse (3 to 6 months)
|Additional Info.||Necessary documents for ordering:|
BRC mice in Publications
Chiu YH, Wu YW, Hung JI, Chen MC.
Epigallocatechin Gallate/L-Ascorbic Acid-Loaded Poly-γ-Glutamate Microneedles with Antioxidant, Anti-inflammatory, and Immunomodulatory Effects for the Treatment of Atopic Dermatitis.
Acta Biomater (2021) 34087444
Chen MC, Chen CS, Wu YW, Yang YY.
Poly-γ-Glutamate microneedles as transdermal immunomodulators for ameliorating atopic dermatitis-like skin lesions in Nc/Nga mice.
Acta Biomater 114 183-192(2020) 32688089
F Zhuo, MAS Abourehab, Z Hussain.
Hyaluronic Acid Decorated Tacrolimus-Loaded Nanoparticles: Efficient Approach to Maximize Dermal Targeting and Anti-dermatitis Efficacy.
Carbohydrate Polymers ()
Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E, Buang F, Sahudin S.
Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model.
Int J Pharm 444(1-2) 109-19(2013) 23337632
Hussain Z, Katas H, Amin MC, Kumulosasi E, Sahudin S.
Antidermatitic perspective of hydrocortisone as chitosan nanocarriers: an ex vivo and in vivo assessment using an NC/Nga mouse model.
J Pharm Sci 102(3) 1063-75(2013) 23303620
Knitlova J, Hajkova V, Voska L, Elsterova J, Obrova B, Melkova Z.
Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.
PLoS One 9(12) e114374(2014) 25486419
Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E.
Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs.
PLoS One 9(11) e113143(2014) 25396426
Yang Z, Liu M, Wang W, Wang Y, Cao B, Gao Y, Chen H, Li T.
Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation.
Sci Rep 7(1) 7918(2017) 28801611