Strain Data Sheet

RBRC01049

Strain Information

Image
BRC No.RBRC01049
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.Cg-Atf2<tm1Sis>/Rbrc
Former Common nameATF2o Knock out (CRE-BP1)-Balb/c
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainBALB/cAJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome.
T Maekawa, F Bernier, M Sato, S Nomura, M Singh, Y Inoue, T Tokunaga, H Imai, M Yokoyama, A Reimold, L H Glimcher, S Ishii
J. Biol. Chem., 274, 17813-17819 (1999). 10364225

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atf2
MGI:109349		activating transcription factor 22Atf2<tm1Sis>
MGI:1857283		targeted mutation 1, Laurie Glimcher
neo neomycin resistance gene (E. coli)2

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cell differentiation (MP:0005076)

  • abnormal lung morphology (MP:0001175)

  • abnormal placenta labyrinth morphology (MP:0001716)

  • abnormal placenta vasculature (MP:0003231)

  • cyanosis (MP:0001575)
    • more 6 phenotypes
  • hypoxia (MP:0005039)

  • improved glucose tolerance (MP:0005292)

  • increased insulin sensitivity (MP:0002891)

  • increased oxygen consumption (MP:0005289)

  • neonatal lethality, complete penetrance (MP:0011087)

  • respiratory failure (MP:0001953)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse activating transcription factor 2 genomic DNA
    Research applicationCancer Research
    Cell Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 274, 17813-17819 (1999).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShunsuke Ishii (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data