BRC No.RBRC01002
SpeciesMus musculus
Strain nameC.Cg-Tg(ITGAM-Aif1)Y/Rbrc
Former Common nameAIF-1 Tgm Line Y BALB/c background
H-2 Haplotype
ES Cell line
Background strainBALB/cAJcl
Strain developmentDeveloped by Drs. Watano and Iwabuchi in 2000. AIF-1 transgenic mice were backcrossed to BALB/c.
Strain descriptionAif1, allograft inflammatory factor-1, was originally identified as one of the expressed genes in infiltrating macrophages. This transgenic strain expresses Aif1 strongly in monocytes and macrophages (CD11b-positive cells), and is useful for analysis of the inflammation and immune response when Aif1 gene is overexpressed.
Colony maintenanceBackcross to BALB/cA (Hemizygote x BALB/cA Jcl)
ReferencesImmunology, 110, 112-119 (2003). 12941148
Am. J. Reprod. Immunol., 50, 104-112 (2003). 14506935
Blood, 85, 319-329 (1995). 7811988
Immunology, 104, 307-316 (2001). 11722645

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Aif1allograft inflammatory factor-1UNAif1human CD11b promoter, hGH


Donor DNAhuman CD11b promoter, mouse AIF-1 cDNA, human growth hormone genomic DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunology, 110, 112-119 (2003).
DepositorKazuya Iwabuchi (Hokkaido University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data