Strain Data Sheet

RBRC00994

Information1

Image
BRC No.RBRC00994
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4-Sh2b1<tm1Ayos>/Rbrc
Former Common nameSH2-B knockout mice, C57BL/6.129 SH2-B -/-
H-2 Haplotype
ES Cell lineAK7 [129S4/SvJaeSor]
Background strainC57BL/6 and 129 mixed
Appearance
Strain developmentC57BL/6 X 129 mix background
Strain description
Colony maintenance
ReferencesNat. Genet., 27, 293-298 (2001). 11242111
Mol. Cell. Biol., 22, 3066-3077 (2002). 11940664

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Sh2bpsm1SH2-B PH domain containing signaling mediator 17Sh2bpsm1 <tm1Ayos>targeted mutation 1, Akihiko YoshimuraIrip, SH2-B, SH2-Bb

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)7neo; neomycin;

Information2

Donor DNAmouse SH2-B PH domain containing signaling mediator genomic DNA, E. coli neo
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 22, 3066-3077 (2002). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The depositor should be a co-author in the articles when the users publish their data using these mice for 1 year after provided.
Users should contact the depositor in the case of application for any patents with the results from these mice.
DepositorSatoshi Takaki (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Wu G, Liu Y, Huang H, Tang Y, Liu W, Mei Y, Wan N, Liu X, Huang C.
SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload.
Cardiovasc Res 107(2) 203-15(2015) 26077624