RBRC00916

Information1

Image
BRC No.RBRC00916
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Irf9<tm1Ttg>/TtgRbrc
Former Common nameIRF-9 KO/C57BL/6J ; p48<-/->; IRF-9<-/->, IRF-9 Knockout mouse, C57BL/6J
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6JJcl
Appearanceblack
Strain developmentDeveloped by Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo. RBRC00915: Backcrossed to BALB/c (N8 generations), RBRC00916: Backcrossed to C57BL/6J (over N13 generations).
Strain descriptionIRF-9 gene knockout mice. Homozygous mutant mice exhibit lower serum interferon levels in response to viral infection. BALB/c background (RBRC00915), C57BL/6 background (RBRC00916).
Colony maintenanceHomozygote x Homozygote
ReferencesGenes Cells, 1, 115-124 (1996). 9078371

Health Report

Examination Date / Room / Rack2020/02/17Room:3-BRack:J
2019/12/16Room:3-BRack:J
2019/10/21Room:3-BRack:J
2019/08/26Room:3-BRack:J
2019/06/17Room:3-BRack:J
2018/08/20Room:3-BRack:F
2018/06/18Room:3-BRack:F
2010/12/13Room:3-DRack:E

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Irf9interferon regulatory factor 914Irf9<tm1Ttg>targeted mutation 1, Tadatsugu Taniguchi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)14mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse IRF-9 genomic DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE and shall limit the use within the scope of the purpose described in this Agreement. The RECIPIENT shall inform the DEPOSITOR about the results obtained by the use of the BIOLOGICAL RESOURCE.
DepositorTadatsugu Taniguchi (The University of Tokyo)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
Strain AvailabilityCryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

Hofer MJ, Li W, Lim SL, Campbell IL.
The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9.
J. Neurosci. 30(3) 1149-57(2010) 20089923

Li W, Hofer MJ, Jung SR, Lim SL, Campbell IL.
IRF7-DEPENDENT, TYPE I INTERFERON PRODUCTION INDUCES LETHAL IMMUNE-MEDIATED DISEASE IN STAT1 KO MICE INFECTED WITH LCMV.
J. Virol. (2014) 24760883

Hofer MJ, Li W, Manders P, Terry R, Lim SL, King NJ, Campbell IL.
MICE DEFICIENT FOR STAT1 BUT NOT STAT2 OR IRF9 DEVELOP A LETHAL CD4+ T-CELL-MEDIATED DISEASE FOLLOWING INFECTION WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS.
J. Virol. (2012) 22496215