RBRC00872

Information1

Image
BRC No.RBRC00872
TypeChromosomal Aberration
SpeciesMus musculus
Strain nameXO
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti with tabby [X<Ta>/X<Ta>, X<Ta>/Y]
agouti with mosaic striped coat [X<Ta>/X]
Strain developmentDeposited by Dr. Nobuo Takagi, Hokkaido University.
Strain descriptionStrain with monosomic X choromosomal aberration (X/O). This strain also has tabby (Eda<Ta>) mutation that affects both the coat color and hair pattern growth. The mice having X<Ta>/O or X<Ta>/Y show yellow coat, no hair on ears and tail, bald patch behind ears, and no guard hairs. Meanwhile, X<Ta>/X females show agouti with mosaic striped due to X-inactivation.agouti with tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs) (X<Ta>/X<Ta>, X<Ta>/Y); agouti with mosaic striped coat (X<Ta>/X)
Colony maintenanceThis strain is maintained using tabby as a phenotypic marker to keep monosomic X chromosome condition. When wild-type female (X/O) is bred to hemizygote tabby male (X<Ta>/Y) in the first generation, hemizygote tabby female (X<Ta>/O) is bred to wild-type male (X/Y) in the second generation. On the contrary, when hemizygote tabby female (X<Ta>/O) is bred to wild-type male (X/Y) in the first generation, wild-type female (X/O) is bred to hemizygote male (X<Ta>/Y) in the second generation.
References

Health Report

Examination Date / Room / Rack2020/06/01Room:3-BRack:K
2020/02/17Room:3-BRack:K
2020/02/03Room:3-BRack:K
2020/01/27Room:3-BRack:K
2019/12/16Room:3-BRack:K
2019/11/22Room:3-BRack:K
2019/11/18Room:3-BRack:K
2019/10/21Room:3-BRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Edaectodysplasin-AXEda<Ta>tabby

Information2

Donor DNA
Research application
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorNobuo Takagi (Hokkaido University)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
Strain AvailabilityCryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.

BRC mice in Publications

Miura K, Murata C, Harikae K, Suzuki H, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y.
Defects in the first wave of folliculogenesis in mouse XO ovaries.
J. Reprod. Dev. 63(3) 333-338(2017) 28392504