Strain Data Sheet

RBRC00846

Strain Information

Image
BRC No.RBRC00846
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CD2-Mafk)1Staka/StakaRbrc
Former Common name194 (low copy), VA-MafK/1 Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Transgenic over-expression of MafK suppresses T cell proliferation and function in vivo.
K Yoh, T Sugawara, H Motohashi, Y Takahama, A Koyama, M Yamamoto, S Takahashi
Genes Cells, 6, 1055-1066 (2001). 11737266

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FLAG FLAG tag (synthetic)UNFLAG
LCR UNLCR
Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)UNMafk human CD2 promoter

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal susceptibility to bacterial infection (MP:0020186)

  • decreased CD4-negative NK T cell number (MP:0013510)

  • decreased CD4-positive NK T cell number (MP:0013519)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)

  • decreased IgG level (MP:0001805)
    • more 9 phenotypes
  • decreased IgG1 level (MP:0008495)

  • decreased IgG2a level (MP:0008496)

  • decreased T cell number (MP:0005018)

  • decreased T cell proliferation (MP:0005095)

  • decreased circulating interleukin-2 level (MP:0008600)

  • decreased circulating interleukin-4 level (MP:0008603)

  • decreased thymocyte number (MP:0000715)

  • increased circulating interferon-gamma level (MP:0008577)

  • increased eosinophil cell number (MP:0005011)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmurine MafK cDNA, human CD2, LCR genomic DNA, FLAG
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes to Cells, 6, 1055-1066 (2001). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorSatoru Takahashi (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data