Strain Data Sheet



BRC No.RBRC00806
SpeciesMus musculus
Strain nameGFP-LC3#53
Former Common nameGFP-LC3#53
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Strain developmentDeveloped by Noboru Mizushima, National Institute for Basic Biology. The transgene was injected into the pronuclei of C57BL/6 x (C57BL/6 x DBA/2)F1 fertilized eggs. The mice were backcrossed to C57BL/6J.
Strain descriptionThese transgenic mice express a fusion cDNA encoding enhanced GFP jointed at its C-terminus to rat microtubule-associated protein 1 light chain 3 beta under the control of the CAG promoter. The occurrence of autophagy in mouse tissues can be monitored by the GFP.
Colony maintenanceCarrier x Carrier, Noncarrier [or Crossing to C57BL/6JJcl]
ReferencesNature, 432, 1032-1036 (2004). 15525940
Mol. Biol. Cell., 15, 1101-1111 (2004). 14699058

Health Report

Examination Date / Room / Rack2021/09/08Room:4-ARack:A


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Map1lc3bmicrotubule-associated protein 1 light (rat)2Map1lc3bmicrotubule associating protein (MAP)1 light chain 3

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
GFPGreen Fluorescent Protein (Aequorea victoria)2CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)


Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), Jellyfish GFP cDNA, rat LC3 cDNA
Research applicationCell Biology Research
Fluorescent Proteins/lacZ System
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Biol. Cell 15, 1101-1111 (2004). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. BIOLOGICAL RESOURCE is limited to for academic research in non-profit organization. Any use of the BIOLOGICAL RESOURCE for profit purposes by a non-profit organization or any use of the BIOLOGICAL RESOURCE by a profit organization requires a separate license from the DEPOSITOR prior to distribution. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorNoboru Mizushima (The University of Tokyo)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Mouse of the Month Mar 2005
Mouse of the Month Mar 2012, Mouse of the Month Oct 2016
Genetic Background
Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. CAGGS MTA (English)
  5. Acceptance of responsibility for living modified organism (Japanese / English)
  6. GFP Transfer License (Japanese / English)
    Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.
Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

Dhingra A, Alexander D, Reyes-Reveles J, Sharp R, Boesze-Battaglia K.
Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina.
Adv. Exp. Med. Biol. 1074 609-616(2018) 29721994

Kanamori H, Takemura G, Maruyama R, Goto K, Tsujimoto A, Ogino A, Li L, Kawamura I, Takeyama T, Kawaguchi T, Nagashima K, Fujiwara T, Fujiwara H, Seishima M, Minatoguchi S.
Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.
Am. J. Pathol. 174(5) 1705-14(2009) 19342365

Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, Sharp FR, Kuan CY.
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.
Am. J. Pathol. 169(2) 566-83(2006) 16877357

Masato KOIKE, Masahiro SHIBATA, Satoshi WAGURI, Kentaro YOSHIMURA, Isei TANIDA, Eiki KOMINAMI, Takahiro GOTOW, Christoph PETERS, Kurt von FIGURA, Noboru MIZUSHIMA, Paul SAFTIG, Yasuo UCHIYAMA
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).
Am. J. Pathol. 167 1713-1728(2005) 16314482

Nishimura F, Naruishi H, Naruishi K, Yamada T, Sasaki J, Peters C, Uchiyama Y, Murayama Y.
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Am. J. Pathol. 161 2047-2052(2002) 12466121

Kanamori H, Takemura G, Goto K, Maruyama R, Ono K, Nagao K, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, Kawasaki M, Fujiwara T, Fujiwara H, Seishima M, Minatoguchi S.
Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion.
Am. J. Physiol. Heart Circ. Physiol. 300(6) H2261-71(2011) 21421825

Kashiwagi A, Hosokawa S, Maeyama Y, Ueki R, Kaneki M, Martyn JA, Yasuhara S.
Anesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle.
Anesthesiology (2014) 25501690

Lo S, Yuan SS, Hsu C, Cheng YJ, Chang YF, Hsueh HW, Lee PH, Hsieh YC.
Lc3 transgene Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice.
Ann. Surg. (2012) 22968077

Inoue J, Nishiumi S, Fujishima Y, Masuda A, Shiomi H, Yamamoto K, Nishida M, Azuma T, Yoshida M.
Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection.
Arch. Biochem. Biophys. 521(1-2) 95-101(2012) 22475450

Fujishima Y, Nishiumi S, Masuda A, Inoue J, Nguyen NM, Irino Y, Komatsu M, Tanaka K, Kutsumi H, Azuma T, Yoshida M.
Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-kappaB activation.
Arch. Biochem. Biophys. 506(2) 223-35(2011) 21156154

Hayashi S, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R.
Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy.
Arterioscler. Thromb. Vasc. Biol. 29(11) 1909-15(2009) 19815818

Caramés B, Olmer M, Kiosses WB, Lotz M.
The relationship of autophagy defects and cartilage damage during joint aging in a mouse model.
Arthritis & rheumatology (Hoboken, N.J.) (2015) 25708836

Caram s B, Kiosses WB, Akasaki Y, Brinson DC, Eap W, Koziol J, Lotz MK.
Glucosamine activates autophagy in vitro and in vivo.
Arthritis Rheum. 65(7) 1843-52(2013) 23606170

Cédéric F. Michiels, Ammar Kurdi, Jean-Pierre Timmermans, Guido R.Y. De Meyer, Wim Martinet.
Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy.
Atherosclerosis 251 319-327 (2016) 27450786

Kanamori H, Takemura G, Goto K, Tsujimoto A, Mikami A, Ogino A, Watanabe T, Morishita K, Okada H, Kawasaki M, Seishima M, Minatoguchi S.
Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes.
Autophagy 11(7) 1146-1160(2015) 26042865

Mintern JD, Macri C, Chin WJ, Panozza SE, Segura E, Patterson NL, Zeller P, Bourges D, Bedoui S, McMillan PJ, Idris A, Nowell CJ, Brown A, Radford KJ, Johnston AP, Villadangos JA.
Differential use of autophagy by primary dendritic cells specialized in cross-presentation.
Autophagy 11(6) 906-917(2015) 25950899

Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, Cecconi F, Grumati P, Bonaldo P.
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice.
Autophagy 11(12) 2142-52.(2015) 26565691

Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR.
Immunohistochemical analysis of macroautophagy: Recommendations and limitations.
Autophagy 9(3) (2012) 23242143

Chong A, Wehrly TD, Child R, Hansen B, Hwang S, Virgin HW, Celli J.
Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.
Autophagy 8(9) 1342-56(2012) 22863802

Tian F, Morimoto N, Liu W, Ohta Y, Deguchi K, Miyazaki K, Abe K.
In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis.
Autophagy 7(9) 985-92(2011) 21628996

Grumati P, Coletto L, Schiavinato A, Castagnaro S, Bertaggia E, Sandri M, Bonaldo P.
Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles.
Autophagy 7(12) 1415-23(2011) 22024752

Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, Zhang X, Liu N, Ikeda Y, Matsuura T, Abe K.
In vivo imaging of autophagy in a mouse stroke model.
Autophagy 6(8) 1107-14(2010) 20930570

Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB.
Short-term fasting induces profound neuronal autophagy.
Autophagy 6(6) 702-10(2010) 20534972

Takemura G, Kanamori H, Goto K, Maruyama R, Tsujimoto A, Fujiwara H, Seishima M, Minatoguchi S.
Autophagy maintains cardiac function in the starved adult.
Autophagy 5(7) 1034-6(2009) 19587530

Martinet W, De Meyer GR, Andries L, Herman AG, Kockx MM.
Detection of autophagy in tissue by standard immunohistochemistry: possibilities and limitations.
Autophagy 2(1) 18809(2006) 16874065

Zheng DM, Bian Z, Furuya N, Oliva Trejo JA, Takeda-Ezaki M, Takahashi K, Hiraoka Y, Mineki R, Taka H, Ikeda S, Komatsu M, Fujimura T, Ueno T, Ezaki J.
A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice.
Biochem. Biophys. Res. Commun. 456(1) 519-26(2014) 25485704

Nakaoka M, Iwai-Kanai E, Katamura M, Okawa Y, Mita Y, Matoba S.
An alpha-adrenergic agonist protects hearts by inducing Akt1-mediated autophagy.
Biochem. Biophys. Res. Commun. (2014) 25446079

Umebayashi H, Mizokami A, Matsuda M, Harada K, Takeuchi H, Tanida I, Hirata M, Kanematsu T.
Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation.
Biochem. Biophys. Res. Commun. (2013) 23399561

Nishiumi S, Fujishima Y, Inoue J, Masuda A, Azuma T, Yoshida M.
Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors.
Biochem. Biophys. Res. Commun. 421(4) 768-72(2012) 22546555

Yoshizaki T, Kusunoki C, Kondo M, Yasuda M, Kume S, Morino K, Sekine O, Ugi S, Uzu T, Nishio Y, Kashiwagi A, Maegawa H.
Autophagy regulates inflammation in adipocytes.
Biochem. Biophys. Res. Commun. (2011) 22155234

Thomes PG, Trambly CS, Thiele GM, Duryee MJ, Fox HS, Haorah J, Donohue TM Jr.
Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment.
Biochem. Biophys. Res. Commun. (2011) 22142844

Kurdi A, Cleenewerck M, Vangestel C, Lyssens S, Declercq W, Timmermans JP, Stroobants S, Augustyns K, De Meyer GRY, Van Der Veken P, Martinet W.
ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice.
Biochem. Pharmacol. 138 150-162(2017) 28642033

Sishi BJ, Loos B, van Rooyen J, Engelbrecht AM.
Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity.
Biochem. Pharmacol. 85(1) 124-34(2013) 23107818

Xu L, Kanasaki M, He J, Kitada M, Nagao K, Jinzu H, Noguchi Y, Maegawa H, Kanasaki K, Koya D.
Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules.
Biochim. Biophys. Acta 1832(10) 1605-12(2013) 23669346

Shiraishi H, Okamoto H, Hara H, Yoshida H.
Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin.
Biochim. Biophys. Acta 1800(3) 405-15(2010) 19914347

Dennem rker J, Lohm ller T, M ller S, Aguilar SV, Tobin DJ, Peters C, Reinheckel T.
Impaired turnover of autophagolysosomes in cathepsin L deficiency.
Biol. Chem. 391(8) 913-22(2010) 20536383

Miki Y, Tanji K, Mori F, Tatara Y, Utsumi J, Sasaki H, Kakita A, Takahashi H, Fimia GM, Wakabayashi K.
AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy.
Brain Pathol. (2016) 27875637

Tambe Y, Yamamoto A, Isono T, Chano T, Fukuda M, Inoue H.
The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
Cancer Lett. 283(1) 74-83(2009) 19368996

Kawaguchi T, Takemura G, Kanamori H, Takeyama T, Watanabe T, Morishita K, Ogino A, Tsujimoto A, Goto K, Maruyama R, Kawasaki M, Mikami A, Fujiwara T, Fujiwara H, Minatoguchi S.
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Cardiovasc. Res. (2012) 22952253

Mizushima N, Yoshimori T, Levine B.
Methods in mammalian autophagy research.
Cell 140(3) 313-26(2010) 20144757

Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T.
Autophagy is essential for hearing in mice.
Cell Death Dis 8(5) e2780(2017) 28492547

Girault V, Gilard V, Marguet F, Lesueur C, Hauchecorne M, Ramdani Y, Laquerrière A, Marret S, Jégou S, Gonzalez BJ, Brasse-Lagnel C, Bekri S.
Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels.
Cell Death Dis 8(2) e2610(2017) 28182007

W?rri A, Cook KL, Hu R, Jin L, Zwart A, Soto-Pantoja DR, Liu J, Finkel T, Clarke R.
Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes.
Cell Death Discov (2018) 30345078

Klinman E, Holzbaur EL.
Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.
Cell Rep 12(3) 462-473(2015) 26166569

Ma B, Cao W, Li W, Gao C, Qi Z, Zhao Y, Du J, Xue H, Peng J, Wen J, Chen H, Ning Y, Huang L, Zhang H, Gao X, Yu L, Chen YG.
Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.
Cell Res. (2014) 24980960

Terada M, Nobori K, Munehisa Y, Kakizaki M, Ohba T, Takahashi Y, Koyama T, Terata Y, Ishida M, Iino K, Kosaka T, Watanabe H, Hasegawa H, Ito H.
Double transgenic mice crossed GFP-LC3 transgenic mice with alphaMyHC-mCherry-LC3 transgenic mice are a new and useful tool to examine the role of autophagy in the heart.
Circ. J. 74(1) 203-6(2010) 19966504

Zhai P, Sciarretta S, Galeotti J, Volpe M, Sadoshima J.
Differential roles of GSK-3beta during myocardial ischemia and ischemia/reperfusion.
Circ. Res. 109(5) 502-11(2011) 21737790

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J.
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.
Circ. Res. 100(6) 914-22(2007) 17332429

Maday S, Holzbaur EL.
Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.
Dev. Cell 30(1) 71-85(2014) 25026034

Kitada M, Ogura Y, Suzuki T, Sen S, Lee SM, Kanasaki K, Kume S, Koya D.
A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity.
Diabetologia (2016) 27020449

Allan Sauvat, Guo Chen, Kevin M?ller, Mingming Tong, Fanny Aprahamian, Sylv?re Durand, Giulia Cerrato, Lucillia Bezu, Marion Leduc, Joakim Franz, Patrick Rockenfeller, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer.
Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids.
EBioMedicine (2018) 29606629

Tang AH, Rando TA.
Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.
EMBO J. (2014) 25316028

Napolitano G, Johnson JL, He J, Rocca CJ, Monfregola J, Pestonjamasp K, Cherqui S, Catz SD.
Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis.
EMBO Mol Med 7(2) 158-74(2015) 25586965

Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, Lim HJ.
Autophagy regulates embryonic survival during delayed implantation.
Endocrinology 152(5) 2067-75(2011) 21363932

Chang AL, Ulrich A, Suliman HB, Piantadosi CA.
Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis.
Free Radic. Biol. Med. 78 179-189(2015) 25450328

Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, Sutton R; and NIHR Pancreas Biomedical Research Unit.
Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.
Gut (2015) 26071131

Ni HM, Bockus A, Boggess N, Jaeschke H, Ding WX.
Activation of autophagy protects against acetaminophen-induced hepatotoxicity.
Hepatology 55(1) 222-32(2012) 21932416

French CJ, Taatjes DJ, Sobel BE.
Autophagy in myocardium of murine hearts subjected to ischemia followed by reperfusion.
Histochem. Cell Biol. 134(5) 519-26(2010) 20931339

Mari o G, Ugalde AP, Salvador-Montoliu N, Varela I, Quir s PM, Cadi anos J, van der Pluijm I, Freije JM, L pez-Ot n C.
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
Hum. Mol. Genet. 17(14) 2196-211(2008) 18443001

Kim SJ, Hong EH, Lee BR, Park MH, Kim JW, Pyun AR, Kim YJ, Chang SY, Chin YW, Ko HJ.
alpha-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation.
Immune Netw 12(6) 253-60(2012) 23396851

Sebastiano Sciarretta, Derek Yee, Narayani Nagarajan, Franca Bianchi, Toshiro Saito, Valentina Valenti, Mingming Tong, Dominic P. Del Re, Carmine Vecchione, Leonardo Schirone, Maurizio Forte, Speranza Rubattu, Akihiro Shirakabe, V. Subbarao Boppana, Massimo Volpe, Giacomo Frati, Peiyong Zhai, Junichi Sadoshima.
Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
J. Am. Coll. Cardiol. (2018) 29724354

Kim SI, Na HJ, Ding Y, Wang Z, Lee SJ, Choi ME.
Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-beta1.
J. Biol. Chem. 287(15) 11677-88(2012) 22351764

Terawaki S, Camosseto V, Prete F, Wenger T, Papadopoulos A, Rondeau C, Combes A, Rodriguez Rodrigues C, Vu Manh TP, Fallet M, English L, Santamaria R, Soares AR, Weil T, Hammad H, Desjardins M, Gorvel JP, Santos MA, Gatti E, Pierre P.
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
J. Cell Biol. 210(7) 1133-52(2015) 26416964

Maday S, Wallace KE, Holzbaur EL.
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.
J. Cell Biol. 196(4) 407-17(2012) 22331844

Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM.
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
J. Clin. Invest. (2013) 24200693

Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya AS.
Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis.
J. Clin. Invest. 119(11) 3340-55(2009) 19805911

Martinet W, De Meyer GR, Andries L, Herman AG, Kockx MM.
In situ detection of starvation-induced autophagy.
J. Histochem. Cytochem. 54(1) 85-96(2006) 16148314

Hoshino A, Matoba S, Iwai-Kanai E, Nakamura H, Kimata M, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Ueyama T, Okigaki M, Matsubara H.
p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia.
J. Mol. Cell. Cardiol. 52(1) 175-84(2012) 22044588

Sandra Maday, Erika L. F. Holzbaur.
Compartment-Specific Regulation of Autophagy in Primary Neurons.
J. Neurosci. 36(22) 5933-5945 (2016) 27251616

Wong YC, Holzbaur EL.
The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation.
J. Neurosci. 34(4) 1293-305(2014) 24453320

Song JW, Misgeld T, Kang H, Knecht S, Lu J, Cao Y, Cotman SL, Bishop DL, Lichtman JW.
Lysosomal activity associated with developmental axon pruning.
J. Neurosci. 28(36) 8993-9001(2008) 18768693

Hylin MJ, Zhao J, Tangavelou K, Rozas NS, Hood KN, MacGowan JS, Moore AN, Dash PK.
A role for autophagy in long-term spatial memory formation in male rodents.
J. Neurosci. Res. (2017) 29230855

Kemball CC, Alirezaei M, Flynn CT, Wood MR, Harkins S, Kiosses WB, Whitton JL.
Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo.
J. Virol. 84(23) 12110-24(2010) 20861268

Zhang Y, Nakano D, Guan Y, Hitomi H, Uemura A, Masaki T, Kobara H, Sugaya T, Nishiyama A.
A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.
Kidney Int. (2018) 30045814

Gubbiotti MA, Neill T, Frey H, Schaefer L, Iozzo RV.
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.
Matrix Biol. 48 14-25(2015) 26344480

Frost LS, Dhingra A, Reyes-Reveles J, Boesze-Battaglia K.
The Use of DQ-BSA to Monitor the Turnover of Autophagy-Associated Cargo.
Meth. Enzymol. 587 43-54(2017) 28253971

Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y.
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.
Mol. Biol. Cell 15 1101-1111(2004) 14699058

Hoshino A, Mita Y, Okawa Y, Ariyoshi M, Iwai-Kanai E, Ueyama T, Ikeda K, Ogata T, Matoba S.
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart.
Nat Commun 4 2308(2013) 23917356

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S.
Plasma cells require autophagy for sustainable immunoglobulin production.
Nat. Immunol. 14(3) 298-305(2013) 23354484

Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J.
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.
Nat. Med. 19(11) 1478-88(2013) 24141421

Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, Otsu K.
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.
Nat. Med. 13(5) 619-24(2007) 17450150

Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, B ck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.
Paneth cells as a site of origin for intestinal inflammation.
Nature (2013) 24089213

Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F.
Ambra1 regulates autophagy and development of the nervous system.
Nature 447(7148) 1121-5(2007) 17589504

Akiko KUMA, Masahiko HATANO, Makoto MATSUI, Akitsugu YAMAMOTO, Haruaki NAKAYA, Tamotsu YOSHIMORI, Yoshinori OHSUMI, Takeshi TOKUHISA, Noboru MIZUSHIMA
The role of autophagy during the early neonatal starvation period.
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