Strain Data Sheet


Strain Information

BRC No.RBRC00757
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Ptpn7<tm1Bwz>/Rbrc
Former Common nameHePTP Knockout mice
H-2 Haplotype
ES Cell lineE14K [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentB6;129P2-Ptpn7<tm1Bwz>. Hematopoietic protein tyrosine phosphatase (HePTP) is a hematopoiesis-specific cytoplasmic protein tyrosine phosphatase that is induced in primary lymphocytes by extracellular stimuli. This knockout mouse strain is useful for investigating the function of the HePTP gene.
Strain descriptionDeveloped by Dr. Haruhiko Suzuki, University of Toronto in 1994. A neomycin selection cassette was inserted into the second exon of the HePTP gene. The HePTP deficient mice were backcrossed to C57BL/6 for 4 times.
Colony maintenanceHomozygous mutant mice were viable and fertile.
ReferencesMol. Cell. Biol., 21, 6851-6858 (2001). 11564869

Health Report

Examination Date / Room / Rack2024/04/08Room:3-BRack:J


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ptpn7protein tyrosine phosphatase, non-receptor type 71Ptpn7<tm1Bwz>targeted mutation 1, Brent W ZankeBPTP-4, HEPTP, LC-PTP, LPTP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)1neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Ptpn7 genomic DNA
Research application
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorHaruhiko Suzuki (Nagoya University)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (3 to 6 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Contact Information
Genotyping protocol -PCR-

BRC mice in Publications

Wang N, Langfelder P, Stricos M, Ramanathan L, Richman JB, Vaca R, Plascencia M, Gu X, Zhang S, Tamai TK, Zhang L, Gao F, Ouk K, Lu X, Ivanov LV, Vogt TF, Lu QR, Morton AJ, Colwell CS, Aaronson JS, Rosinski J, Horvath S, Yang XW.
Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.
Neuron 110(20) 3318-3338.e9(2022) 36265442