Strain Information | |
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Image | |
BRC No. | RBRC00755 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129P2-Fcer2a<tm1Kik>/KikRbrc |
Former Common name | CD23 Knockout mice |
H-2 Haplotype | |
ES Cell line | E14.1 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Research Institute, Osaka Medical Center for Maternal and Child Health. |
Strain description | |
Colony maintenance | |
References | The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Yoshida K, Tanaka T, Suemura M, Matsumoto N, Kojima S, et a l Proc. Natl. Acad. Sci. USA, 91, 6835-6839 (1994). 8041705Complete genomic sequence of the murine low affinity Fc receptor for IgE. Demonstration of alternative transcripts and conserved sequence elements. Richards M L, Katz D H, Liu F T J. Immunol., 147, 1067-1074 (1991). 1861070 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 8 | Fcer2a | targeted mutation 1, Hitoshi Kikutani | |||
neo | neomycin resistance gene (E. coli) | 8 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, HSV tk poly A (pMC1 neo-poly A GenBank:U43612), mouse CD23 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 91, 6835-6839 (1994). |
Depositor | Hitoshi Kikutani (Osaka University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Obayashi K, Doi T, Koyasu S. Dendritic cells suppress IgE production in B cells. Int Immunol 19(2) 217-26(2007) 17208926 |