RBRC00754

Information1

Image
BRC No.RBRC00754
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc
Former Common nameCD40 transgenic mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Hitoshi Kikutani, Research Institute for Microbial Diseases, Osaka University in 2002.
Strain descriptionTransgenic mice expressing wild-type human CD40 gene in a mouse CD40 deficient background. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation.
Colony maintenance
ReferencesNature, 316, 67-69 (1985). 2409451
Int. Immunol., 14, 319-329 (2002). 11867568

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tnfrsf5tumor necrosis factor receptor superfamily, member 52Tnfrsf5<tm1Kik>targeted mutation 1, Hitoshi Kikutani

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)2

Gene symbolGene nameChr.Allele symbolAllele namePromoter
TNFRSF5tumor necrosis factor receptor superfamily, member 5 (human)UNTNFRSF5mouse E m, IgH promoter, rabbit beta-globin poly A

Information2

Donor DNAhuman CD40 cDNA, mouse E m, IgH promoter, rabbit beta-globin poly A, E. coli neo, mouse CD40 genomic DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Inter. Immunol., 14, 319-329 (2002).
DepositorHitoshi Kikutani (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data