Strain Data Sheet

RBRC00753

Information1

Image
BRC No.RBRC00753
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Sema4d<tm1Kik>/Rbrc
Former Common nameCD100 Knockout mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
ReferencesImmunity, 13, 633-642 (2000). 11114376

Health Report

Examination Date / Room / Racknull

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Sema4dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D13Sema4d<tm1Kik>targeted mutation 1, Hitoshi KikutaniCD100, coll-4, M-sema G, Semacl2, SEMAJ, Semaj, semaphorin H, Semcl2

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)13neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse CD100 genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 13, 633-642 (2000).
DepositorHitoshi Kikutani (Osaka University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Zhang C, Qiao H, Guo W, Liu Y, Yang L, Liu Y, Jin B, Fu M, Wang G, Li W.
CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis.
Cancer Lett 455 1-13(2019) 30981760

Xiao C, Luo Y, Zhang C, Zhu Z, Yang L, Qiao H, Fu M, Wang G, Yao X, Li W.
Negative regulation of dendritic cell activation in psoriasis mediated via CD100-plexin-B2.
J Pathol 250(4) 409-419(2020) 31943215

Zhu Z, Luo Y, Yu J, Gao J, Zhang Y, Xiao C, Zhang C, Wang G, Liu Y, Fu M, Yao X, Li W.
Sema4D is required in both the adaptive and innate immune responses of contact hypersensitivity.
Mol Immunol 78 98-104(2016) 27614265