BRC No.RBRC00695
SpeciesMus musculus
Strain nameB6.Cg-Tg(KRT14-HGF)43Takk/Rbrc
Former Common namehk14-HGF (human cytokeratin14 promoter + human hepatocyte growth factor)
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C +/+]
black with an aberrant pigmentation in the skin [a/a B/B C/C Tg/?]
Strain developmentDeveloped by Dr. Takahiro Kunisada at Tottori University in 2000. The human HGF cDNA fragment under the contorl of human keratin 14 promoter was injected into the pronuclei of B6D2F1 fertilized eggs.
Strain descriptionThese transgenic mice develop prominent epidermal pigmentation by overexpression of the human HGF gene controlled by the human keratin 14 promoter. The phenotypes of these transgenic mice conform with that of human dermal melanocytosis. This strain is a useful animal model for dermal melanocytosis.
Colony maintenanceSibling Mating (Hemizygote x wild-type, Hemizygote)
ReferencesMech. Dev., 94, 67-78 (2000). 10842060

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
HGFhepatocyte growth factor (human)UNHGF<Tg(KRT14-HGF)43Takk>transgene insertion 43, Takahiro Kunisadahuman cytokeratin14 promoter


Donor DNAhuman cytokeratin14 promoter, rabbit beta globin intron, human hepatocyte growth factor cDNA, human cytokeratin14 poly A
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorTakahiro Kunisada (Gifu University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-
Lab HP (Japanese)

BRC mice in Publications

No Data