Strain Data Sheet

RBRC00524

Strain Information

Image
BRC No.RBRC00524
TypeMajor Histocompatibility Complex (H2) Congenic
SpeciesMus musculus
Strain nameBALB.B/Ola
Former Common nameBALB.B/Ola
H-2 HaplotypeH2<b>
ES Cell line
Background strainBALB/c
Appearancealbino (A/A b/b c/c)
Strain developmentBALB.B/Ola (C.B10-H2<b>/OlaMs). Major Histocompatibility Complex (H2) Congenic strain. This strain was created by transferring the H2b haplotype from C57BL/10Sn mice into the BALB/c strain by backcrossing. This mouse is useful for Immunology and Inflammation research. Developed by Harlan-OLAC Ltd., Oxon., England. This strain was introduced to National Institute of Genetics at November 1981 and deposited to the RIKEN BRC in October 2002 by Dr. Toshihiko Shiroishi. Generation: F?+F50F5+F1〜5
Strain descriptionBALB.B/Ola (C.B10-H2<b>/OlaMs). Major Histocompatibility Complex (H2) Congenic strain. This strain was created by transferring the H2b haplotype from C57BL/10Sn mice into the BALB/c strain by backcrossing. This mouse is useful for Immunology and Inflammation research.
Colony maintenanceSibling Maitng (sister x brother mating). Reproductive performance is not good.
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
H2histocompatibility-2, MHC17H2b variant

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell differentiation(MP:0002145)

  • abnormal cytokine secretion(MP:0003009)

  • abnormal double-negative T cell morphology(MP:0002407)

  • abnormal double-positive T cell morphology(MP:0002408)

  • abnormal liver physiology(MP:0000609)
    • more 11 phenotypes
  • abnormal negative T cell selection(MP:0004918)

  • decreased double-positive T cell number(MP:0005092)

  • decreased hematocrit(MP:0000208)

  • decreased physiological sensitivity to xenobiotic(MP:0008874)

  • decreased susceptibility to autoimmune diabetes(MP:0004804)

  • decreased susceptibility to parasitic infection(MP:0005026)

  • decreased thymocyte number(MP:0000715)

  • increased anti-double stranded DNA antibody level(MP:0004762)

  • increased autoantibody level(MP:0003725)

  • periinsulitis(MP:0005580)

  • spleen hypoplasia(MP:0000694)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshihiko Shiroishi (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Tashiro-Yamaji J, Shimizu T, Hayashi M, Yamana H, Tanigawa N, Uchiyama K, Kubota T, Yoshida R.
    Specific binding of HLA-B44 to human macrophage MHC receptor 1 on monocytes.
    Gene 501(2) 127-34(2012) 22525042