BRC No.RBRC00455
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Skp2<tm1Kin>
Former Common nameSkp2 Knockout mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Kei-ichi Nakayama, Kyusyu University in 2000.
Strain descriptionB6.129P2-Skp2<tm1Kin>. Skp2 gene knock-out mice. Homozygous mutant mice are viable, but show reduced growth rate and increased apoptosis of cells.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
ReferencesEMBO J., 19, 2069-2081 (2000). 10790373

Health Report

Examination Date / Room / Rack2007/09/18Room:4-ARack:I


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Skp2S-phase kinase-associated protein 2 (p45)15Skp2<tm1Kin>targeted mutation 1, Kei-ichi Nakayama

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)15mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAPGK promoter (mouse phosphoglycerate kinase gene promoter), Neomycin resistance gene (neomycin phosphotransferase II (nptll) gene of the transposon Tn5 in Escherichia coli K12), PGK polyA (mouse phosphoglycerate kinase gene terminater), mouse Skp2 genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorKeiichi Nakayama (Kyushu University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data