Strain Data Sheet


Strain Information

BRC No.RBRC00432
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameRLC/Stm
Former Common nameRLC/Stm
H-2 Haplotype
ES Cell line
Background strainRLC/Stm
Strain developmentSpontaneous mutation originally arose in CXSN/A strain. The mutant mice were bred with a BALB/cHeA and then maintained by inbreeding.
Strain descriptionrlc, Rupture of Lens Cataract. Spontaneous recessive mutation arose in CXSN/A mice. The mutation as a deletion of 27 bp at the end of 15th of Dock5 gene.
Colony maintenance
ReferencesGraefe's Arch. Clin. Exp. Ophthalmol., 238, 970-978 (2000). 11196360
Exp. Eye Res., 64, 107-113 (1997). 9093026
Genomics, 36, 553-554 (1996). 8884285

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Dock5dedicator of cytokinesis 514Dock5<rlc>rupture of lens cataractlr2

Ordering Information

Donor DNA
Research applicationMouse Models for Human Disease
Sensorineural Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorYoshibumi Matsushima (Saitama Cancer Center)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Hiai H, Tsuruyama T, Yamada Y.
Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.
Cancer Sci 94(10) 847-50(2003) 14556656

Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H.
Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse.
Exp Eye Res 86(5) 828-34(2008) 18396277