Strain Data Sheet


Strain Information

BRC No.RBRC00422
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC.Cg-Cpox<nct>/JmsRbrc
Former Common nameNCT, BALB/c-nct/nct
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A b/b c/c]
Strain developmentCataract mutation arose spontaneously in the multiple breeding colony. The mutant mice were backcrossed to BALB/c (1988).
Strain descriptionNakano cataract mice, spontaneous recessive mutant. Homozygous mutant mice develop cataracts. A spontaneous G to T transversion was occurred in the Cpox gene, resulting in the amino acid substitution of Leu for Arg at position 380.
Colony maintenanceSibling Mating (Homozyogote x Homozygote)
ReferencesGenomics, 50, 119-120 (1998). 9628833
Exp. Eye Res., 75, 745-751 (2002). 12470976
Exp. Eye Res., 112, 45-50 (2013). 23631845

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cpoxcoproporphyrinogen oxidase16Cpox<nct>Nakano cataract

Ordering Information

Donor DNA
Research applicationSensorineural Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorHiroshi Hiai (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M.
A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
Exp Anim 64(2) 171-9(2015) 25736709

Liu C, Miyahara H, Dai J, Cui X, Li Y, Kang X, Higuchi K, Mori M.
Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpoxnct mice.
Exp Eye Res 215 108905(2022) 34968474

Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K.
Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
Exp Eye Res 112 45-50(2013) 23631845

Narita M, Wang Y, Kita A, Omi N, Yamada Y, Hiai H.
Genetic analysis of Nakano Cataract and its modifier genes in mice.
Exp Eye Res 75(6) 745-51(2002) 12470976

Xiaojing Kang, Shin Shimada, Hiroki Miyahara, Keiichi Higuchi, Masayuki Mori
BALB.NCT-Cpox is a unique mouse model of hereditary coproporphyria
Molecular Genetics and Metabolism Reports 35 100964(2023) 36967721