BRC No.RBRC00422
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC.Cg-Cpox<nct>/JmsRbrc
Former Common nameNCT, BALB/c-nct/nct
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A b/b c/c]
Strain developmentCataract mutation arose spontaneously in the multiple breeding colony. The mutant mice were backcrossed to BALB/c (1988).
Strain descriptionNakano cataract mice, spontaneous recessive mutant. Homozygous mutant mice develop cataracts. A spontaneous G to T transversion was occurred in the Cpox gene, resulting in the amino acid substitution of Leu for Arg at position 380.
Colony maintenanceSibling Mating (Homozyogote x Homozygote)
ReferencesExp. Eye Res., 75, 745-751 (2002). 12470976
Exp. Eye Res., 112, 45-50 (2013). 23631845
Genomics, 50, 119-120 (1998). 9628833

Health Report

Examination Date / Room / Rack2007/10/15Room:3-CRack:K


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Cpoxcoproporphyrinogen oxidase16Cpox<nct>Nakano cataract


Donor DNA
Research applicationSensorineural Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorHiroshi Hiai (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.

BRC mice in Publications

Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M.
A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
Exp. Anim. 64(2) 171-9(2015) 25736709

Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K.
Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
Exp. Eye Res. (2013) 23631845

Makiko NARITA, Yun WANG, Akiyo KITA, Natsue OMI, Yoshihiro YAMADA, Hiroshi HIAI
Genetic Analysis of Nakano Cataract and Its Modifier Genes in Mice
Exp. Eye Res. 75 745-751(2002) 12470976