Strain Data Sheet

RBRC00422

Strain Information

Image
BRC No.RBRC00422
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC.Cg-Cpox<nct>/JmsRbrc
Former Common nameNCT, BALB/c-nct/nct
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [A/A b/b c/c]
Strain developmentCataract mutation arose spontaneously in the multiple breeding colony. The mutant mice were backcrossed to BALB/c (1988).
Strain descriptionNakano cataract mice, spontaneous recessive mutant. Homozygous mutant mice develop cataracts. A spontaneous G to T transversion was occurred in the Cpox gene, resulting in the amino acid substitution of Leu for Arg at position 380.
Colony maintenanceSibling Mating (Homozyogote x Homozygote)
References
Mapping of Nakano cataract gene nct on mouse chromosome 16.
H Hiai, S Kato, Y Horiuchi, R Shimada, T Tsuruyama, T Watanabe, A Matsuzawa
Genomics, 50, 119-120 (1998). 9628833

Genetic analysis of Nakano Cataract and its modifier genes in mice.
Makiko Narita, Yun Wang, Akiyo Kita, Natsue Omi, Yoshihiro Yamada, Hiroshi Hiai
Exp. Eye Res., 75, 745-751 (2002). 12470976

Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
Masayuki Mori, Saki Gotoh, Shigeru Taketani, Hiroshi Hiai, Keiichi Higuchi
Exp. Eye Res., 112, 45-50 (2013). 23631845

Health Report

Examination Date / Room / Rack2026-06-22Room:3-ARack:KSentinel mouse program
2026-04-06Room:3-ARack:KSentinel mouse program
2026-01-19Room:3-ARack:KSentinel mouse program
2025-11-10Room:3-ARack:KSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cpox
MGI:104841		coproporphyrinogen oxidase16Cpox<nct>
MGI:1856966		Nakano cataract
  • harderoporphyria(MedGEN)

  • hereditary coproporphyria(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal lens fiber morphology (MP:0002840)

  • abnormal lens morphology (MP:0001303)

  • cataract (MP:0001304)

  • hydropic eye lens fibers (MP:0001309)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationSensorineural Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHiroshi Hiai (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Xiaojing Kang, Shin Shimada, Hiroki Miyahara, Keiichi Higuchi, Masayuki Mori
    BALB.NCT-Cpox is a unique mouse model of hereditary coproporphyria
    Molecular Genetics and Metabolism Reports 35 100964(2023) 36967721
    Liu C, Miyahara H, Dai J, Cui X, Li Y, Kang X, Higuchi K, Mori M.
    Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpoxnct mice.
    Exp Eye Res 215 108905(2022) 34968474
    Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M.
    A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
    Exp Anim 64(2) 171-9(2015) 25736709
    Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K.
    Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
    Exp Eye Res 112 45-50(2013) 23631845
    Narita M, Wang Y, Kita A, Omi N, Yamada Y, Hiai H.
    Genetic analysis of Nakano Cataract and its modifier genes in mice.
    Exp Eye Res 75(6) 745-51(2002) 12470976