RBRC00407

Information1

Image
BRC No.RBRC00407
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Tcrd<tm1Mom>/ItoRbrc
Former Common nameTCR delta-KO, TCRd KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Strain descriptionDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Colony maintenanceSibling MatingHomozygous mutant mice are viable and fertile.
ReferencesCell, 72, 337-348 (1993). 8381716

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
TcrdT-cell receptor delta chain14Tcrd<tm1Mom>targeted mutation 1, Peter Mombaerts

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)14mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse T-cell receptor delta chain genome DNA
Research applicationCell Biology Research
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Itohara et al., Cell, 72, 337-348 (1993).
DepositorShigeyoshi Itohara (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T.
Involvement of NK1.1+ {gamma}{delta}T Cells in the IL-18 Plus IL-2-Induced Interstitial Lung Disease.
Am. J. Respir. Cell Mol. Biol. (2011) 21257923

Segawa S, Goto D, Iizuka A, Kaneko S, Yokosawa M, Kondo Y, Matsumoto I, Sumida T.
The regulatory role of IFN-γ producing gammadelta T cells via the suppression of Th17 cell activity in bleomycin-induced pulmonary fibrosis.
Clin. Exp. Immunol. (2016) 27083148