RBRC00388

Information1

Image
BRC No.RBRC00388
TypeSpontaneous Mutation
SpeciesMus musculus
Strain namePROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common namePROD-rol/+
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti with white spot [A/A B/? C/C s/s]
Strain developmentDeveloped by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969.
Strain descriptionRolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy.
Colony maintenanceHomozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.homozygous females are fertile but do not breed well.
ReferencesNeurosci. Lett., 266, 49-52 (1999). 10336181
Dev. Psycobiology, 19, 67-77 (1986). 3699253
J. Neurosci., 20, 5654-5662 (2000). 10908603
Neurosci. Res., 5, 316-324 (1988). 2897649
実験動物, 22, 281-288 (1973).
チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999).
実験動物の遺伝的コントロール(富田武,江崎考三郎,早川純一郎,編)ソフトサイエンス社, 東京, pp. 248-259 (1983).
名古屋大学環境医学研究所年報, 27, 195-197 (1976).
医学のあゆみ, 101, 74-75 (1977).
Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).
Jpn. J. Genet., 56, 295-299 (1981).
名古屋大学環境医学研究所年報, 28, 212-213 (1977).
名古屋大学環境医学研究所年報, 27, 193-194 (1976).
名古屋大学環境医学研究所年報, 26, 7-9 (1975).
Biomed. Res., 1, 88-90 (1980).

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit8Cacna1a<tg-rol>rolling Nagoya

Information2

Donor DNA
Research applicationDevelopmental Biology Research
Genetics Research
Neurobiology Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorSenichi Oda (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
Behav. Brain Res. (2013) 24177210

Takahashi E, Niimi K, Itakura C.
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Behav. Brain Res. 204(1) 241-5(2009) 19467269

Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
Analysis of ischemic neuronal injury in Cav2.1 channel alpha 1 subunit mutant mice.
Biochem. Biophys. Res. Commun. (2013) 23545255

Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
Blood 107(3) 1078-84(2006) 16219795

Kim TY, Niimi K, Takahashi E.
Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury.
Brain Res. (2016) 27840189

Takahashi E, Niimi K, Itakura C.
Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
Brain Res. 1279 16983 (2009) 19446536

Takahashi E, Niimi K.
Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
Exp. Gerontol. 44(4) 274-9(2009) 19073246

Takahashi E, Niimi K, Itakura C.
Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
J. Mol. Neurosci. 41(2) 223-9(2010) 19609731

Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Ca(2+) channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca(2+) channel mutant mouse, rolling mouse Nagoya.
Neurosci. Res. 73(3) 199-206(2012) 22575052

Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
Neuroscience 160(1) 165-73(2009) 19248821