RBRC00379

Information1

Image
BRC No.RBRC00379
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6.Cg-Hm+/+Reln<rl>/NemOdaRbrc
Former Common nameC57BL/6-Hm/+-rl/+
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Sen-ichi Oda, Nagoya University. This strain was generated by crossbreeding heterozygotic reeler (C57BL/6-rl) and hammer-toe (C57BL/6-Hm) mutants.
Strain descriptionB6.Cg-Hm+/+Reln<rl>. This strain was generated by crossbreeding heterozygotic reeler (Reln<rl>) and hammer-toe (Hm) mutant mice to facilitate distinguishing between heterozygous reeler mice (rl/+) and wildtype. The Hammer-toe semidominant gene is located near reeler locus on the homologous chromosome. The reeler mutation causes an abnormal pattern in the layering of neurons in the neocortex and the cerebellum. The reeler homozygous (rl/rl) mutant mice show impaired motor coordination, tremors and ataxia. The hammer-toe homozygous (Hm/Hm) mutant mice show markedly-flexed digits having a fusion of the interdigital tissues, whereas in Hm heterozygotes (Hm/+) the degree of flexion is not so severe compared to those of homozygotes.
Colony maintenanceSibling mating (Hm +/+ rl x Hm +/+ rl)Reeler homozygous mutant mice show impaired motor coordination, tremors and ataxia, and die by 4 weeks of age. Hammer toe homozygous mutant mice are viable and fertile.
ReferencesAnat. Embryol (Berl) 188, 317-329 (1993). 7506500
名古屋大学環境医学研究所年報, 40, 266-267(1989).

Health Report

Examination Date / Room / Rack2006/04/04Room:3-7Rack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Relnreelin5Reln<rl>reeler

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Hmhammer toe5Hmhammertoe

Information2

Donor DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
DepositorSenichi Oda (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data