Strain Data Sheet

RBRC00301

Strain Information

Image
BRC No.RBRC00301
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Rela<tm1Yuo>/2Rbrc
Former Common nameRelA KO, RKO-2
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack
Strain development
Strain description
Colony maintenance
References
Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality.
Doi T S, Marino M W, Takahashi T, Yoshida T, Sakakura T, Old L J, Obata Y
Proc. Natl. Acad. Sci. USA, 96, 2994-2999 (1999). 10077625

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses.
Doi T S, Takahashi T, Taguchi O, Azuma T, Obata Y
J. Exp. Med., 185, 953-961 (1997). 9120401

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)19Relatargeted mutation 1, Yuichi Obata
  • mucocutaneous ulceration, chronic(MedGEN)
    • neoneomycin resistance gene (E. coli)19herpes simplex virus thymidine kinase promoter (HSV tk promoter)
  • mucocutaneous ulceration, chronic(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal hepatocyte morphology(MP:0000607)

  • abnormal liver morphology(MP:0000598)

  • abnormal lymphocyte physiology(MP:0003945)

  • abnormal myogenesis(MP:0000729)

  • decreased B cell proliferation(MP:0005093)
    • more 5 phenotypes
  • decreased IgA level(MP:0001807)

  • decreased IgG1 level(MP:0008495)

  • decreased T cell proliferation(MP:0005095)

  • decreased double-positive T cell number(MP:0005092)

  • lethality throughout fetal growth and development, complete penetrance(MP:0011099)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse RelA genomic DNA
    Research applicationCell Biology Research
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Exp Med., 185, 953-961 (1997). Any patent rights and other intellectual properties are retained by the depositor. Users should contact the depositor in the case of application for any patents with the results from these mice.
    DepositorTakahiro Doi (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data