RBRC00300

Information1

Image
BRC No.RBRC00300
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Rela<tm1Yuo>/1Rbrc
Former Common nameRelA KO, RKO-1
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack
Strain development
Strain description
Colony maintenance
ReferencesProc. Natl. Acad. Sci. USA, 96, 2994-2999 (1999). 10077625
J. Exp. Med., 185, 953-961 (1997). 9120401

Health Report

Examination Date / Room / Rack2013/09/24Room:4-ARack:J
2013/07/22Room:4-ARack:J
2013/05/20Room:4-ARack:J
2013/03/25Room:4-ARack:J
2013/01/21Room:4-ARack:J
2012/11/26Room:4-ARack:J
2012/09/24Room:4-ARack:J
2012/07/23Room:4-ARack:J

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)19Rela<tm1Yuo>targeted mutation 1, Yuichi Obata

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)19herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Information2

Donor DNAmouse RelA genomic DNA, E. coli neo, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
Research applicationCell Biology Research
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Exp Med., 185, 953-961 (1997). Any patent rights and other intellectual properties are retained by the depositor. Users should contact the depositor in the case of application for any patents with the results from these mice.
DepositorTakahiro Doi (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS.
A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription.
J. Immunol. 179(10) 6596-603(2007) 17982049

Kawauchi K, Araki K, Tobiume K, Tanaka N.
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Nat. Cell Biol. 10(5) 611-8(2008) 18391940