Strain Data Sheet

RBRC00222

Strain Information

Image
BRC No.RBRC00222
TypeInbred
SpeciesMus musculus
Strain nameSL/Kh
Former Common name
H-2 Haplotype
ES Cell line
Background strainSL/KhStm
Appearancealbino [A/A, B/B, c/c]
Strain developmentThe spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.High incidence of pre-B lymphomas at early age
Strain descriptionSL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.
Colony maintenanceSibling Mating
References
Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.
Lu L M, Shimada R, Higashi S, Zeng Z, Hiai H
Cancer Res., 59, 2593-2595 (1999). 10363979

Genetic predisposition to pre-B lymphomas in SL/Kh strain mice.
Yamada Y, Matsushiro H, Ogawa M S, Okamoto K, Nakakuki Y, Toyokuni S, Fukumoto M, Hiai H
Cancer Res., 54, 403-407 (1994). 8275476

T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models.
Yamada Y, Shisa H, Matsushiro H, Kamoto T, Kobayashi Y, Kawarai A, Hiai H
J. Exp. Med., 180, 2155-2162 (1994). 7964490

Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Okamoto K, Yamada Y, Ogawa M S, Toyokuni S, Nakakuki Y, Ikeda H, Yoshida O, Hiai H
Cancer Res., 54, 399-402 (1994). 8275475

Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H
Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235

The origin of SL family mice.
Abujiang P, Yamada Y, Haller O, Kobayashi H, Kamoto T, Lu L M, Ogawa M, Ishimoto A, Katoh H, Kanehira K, Ikegami S, Fukumoto M, Hiai H
Lab. Anim. Sci., 46, 410-417 (1996). 8872992

Epigenetic control of endogenous ecotropic virus expression in SL/Ni mice.
Hiai H, Buma Y O, Ikeda H, Moriwaki K, Nishizuka Y
J. Natl. Cancer Inst., 79, 781-787 (1987). 3477660

Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.
Pataer A, Kamoto T, Lu L M, Yamada Y, Hiai H
Cancer Res., 56, 3716-3720 (1996). 8706013

Health Report

Examination Date / Room / Rack2024/07/08Room:3-BRack:L

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bomb1bone marrow pre-B 13Bomb1
Tlsm1thymic lymphoma susceptible 17Tlsm1thymic lymphoma susceptible 1; SL/Kh

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • increased T cell derived lymphoma incidence(MP:0002024)

  • increased lymphoma incidence(MP:0012431)

  • increased pre-B cell number(MP:0003132)
  • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHayase Shisa (Saitama Cancer Center)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    Strain AvailabilityCryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
    Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
    Blood 100(1) 238-45(2002) 12070033
    Jin G, Tsuruyama T, Yamada Y, Hiai H.
    Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.
    Cancer Sci 94(9) 791-5(2003) 12967477
    Hiai H, Tsuruyama T, Yamada Y.
    Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.
    Cancer Sci 94(10) 847-50(2003) 14556656
    Tsuruyama T, Hiratsuka T, Aini W, Nakamura T.
    STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
    J Cell Biochem 117(11) 2630-42(2016) 27018255
    Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
    Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
    Leuk Res 32(2) 309-14(2008) 17617450
    Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
    ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
    Oncogene 35(25) 3227-38(2016) 26522721
    Tsuruyama T, Liu W, Yoshikawa K.
    In vitro murine leukemia retroviral integration and structure fluctuation of target DNA.
    PLoS One 7(2) e31533(2012) 22348097
    Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H.
    Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
    Proc Natl Acad Sci U S A 99(12) 8253-8(2002) 12048235
    Hiai H.
    Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S.
    Springer-Verlag 227-244(2008)
    Tatsuaki Tsuruyama.
    DNA insertion mutations can be predicted by a periodic probability function.
    arXiv (2017)