BRC No.RBRC00222
SpeciesMus musculus
Strain nameSL/Kh
Former Common name
H-2 Haplotype
ES Cell line
Background strainSL/KhStm
Appearancealbino [A/A, B/B, c/c]
Strain developmentThe spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.
Strain descriptionSL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.
Colony maintenanceSibling MatingHigh incidence of pre-B lymphomas at early age
ReferencesJ. Natl. Cancer Inst., 79, 781-787 (1987). 3477660
Cancer Res., 54, 399-402 (1994). 8275475
Cancer Res., 56, 3716-3720 (1996). 8706013
Lab. Anim. Sci., 46, 410-417 (1996). 8872992
Cancer Res., 54, 403-407 (1994). 8275476
Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235
Cancer Res., 59, 2593-2595 (1999). 10363979
J. Exp. Med., 180, 2155-2162 (1994). 7964490

Health Report

Examination Date / Room / Rack2009/10/19Room:3-CRack:F


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Bomb1bone marrow pre-B 13Bomb1<SL/Kh>

Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tlsm1thymic lymphoma susceptible 17Tlsm1<SL/Kh>thymic lymphoma susceptible 1; SL/Kh


Donor DNA
Research applicationCancer Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorHayase Shisa (Saitama Cancer Center)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

Scott C KOGAN, Jerrold M WARD, Miriam R ANVER, Jules J BERMAN, Cory BRAYTON, Robert D CARDIFF, John S CARTER, Sherri de CORONADO, James R DOWNING, Torgny N FREDRICKSON, Diana C HAINES, Alan W HARRIS, Nancy Lee HARRIS, Hiroshi HIAI, Elaine S JAFFE, Ian C M MACLENNAN, Pier Paolo PANDOLFI, Paul K PATTENGALE, Archibald S PERKINS, R Mark SIMPSON, Mark S TUTTLE, Joanne F WONG, Herbert C 3rd MORSE
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Blood 100 238-245(2002) 12070033

Guang JIN, Tatsuaki TSURUYAMA, Yoshihiro YAMADA, Hiroshi HIAI
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.
Cancer Sci. 94 791-795(2003) 12967477

Tsuruyama T, Hiratsuka T, Wulamujiang A, Nakamura T.
STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
J. Cell. Biochem. (2016) 27018255

Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
Leuk. Res. 32(2) 309-14(2008) 17617450

Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
Oncogene (2015) 26522721

Tsuruyama T, Liu W, Yoshikawa K.
In vitro murine leukemia retroviral integration and structure fluctuation of target DNA.
PLoS ONE 7(2) e31533(2012) 22348097

Tatsuaki TSURUYAMA, Takuro NAKAMURA, Guang JIN, Munetaka OZEKI, Yoshihiro YAMADA, Hiroshi HIAI
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.
Proc. Natl. Acad. Sci. U.S.A. 99 8253-8258(2002) 12048235

Hiai H.
Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S, Springer-Verlag.
Springer-Verlag 227-244(2008)

Tatsuaki Tsuruyama.
DNA insertion mutations can be predicted by a periodic probability function.
arXiv (2017)