Strain Information | |
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Image | |
BRC No. | RBRC00222 |
Type | Inbred |
Species | Mus musculus |
Strain name | SL/Kh |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | SL/KhStm |
Appearance | albino [A/A, B/B, c/c] |
Strain development | The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.High incidence of pre-B lymphomas at early age |
Strain description | SL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model. |
Colony maintenance | Sibling Mating |
References | Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice. Lu L M, Shimada R, Higashi S, Zeng Z, Hiai H Cancer Res., 59, 2593-2595 (1999). 10363979Genetic predisposition to pre-B lymphomas in SL/Kh strain mice. Yamada Y, Matsushiro H, Ogawa M S, Okamoto K, Nakakuki Y, Toyokuni S, Fukumoto M, Hiai H Cancer Res., 54, 403-407 (1994). 8275476T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models. Yamada Y, Shisa H, Matsushiro H, Kamoto T, Kobayashi Y, Kawarai A, Hiai H J. Exp. Med., 180, 2155-2162 (1994). 7964490Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice. Okamoto K, Yamada Y, Ogawa M S, Toyokuni S, Nakakuki Y, Ikeda H, Yoshida O, Hiai H Cancer Res., 54, 399-402 (1994). 8275475Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H Proc. Natl. Acad. Sci. USA, 99, 8253-8258 (2002). 12048235The origin of SL family mice. Abujiang P, Yamada Y, Haller O, Kobayashi H, Kamoto T, Lu L M, Ogawa M, Ishimoto A, Katoh H, Kanehira K, Ikegami S, Fukumoto M, Hiai H Lab. Anim. Sci., 46, 410-417 (1996). 8872992Epigenetic control of endogenous ecotropic virus expression in SL/Ni mice. Hiai H, Buma Y O, Ikeda H, Moriwaki K, Nishizuka Y J. Natl. Cancer Inst., 79, 781-787 (1987). 3477660Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Pataer A, Kamoto T, Lu L M, Yamada Y, Hiai H Cancer Res., 56, 3716-3720 (1996). 8706013 |
Health Report | |
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Examination Date / Room / Rack | 2024/07/08Room:3-BRack:L |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Bomb1 | bone marrow pre-B 1 | 3 | Bomb1 | ||||
Tlsm1 | thymic lymphoma susceptible 1 | 7 | Tlsm1 | thymic lymphoma susceptible 1; SL/Kh |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Cancer Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Hayase Shisa (Saitama Cancer Center) |
Strain Status | Live mice Frozen embryos |
Strain Availability | Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 100(1) 238-45(2002) 12070033 |
Jin G, Tsuruyama T, Yamada Y, Hiai H. Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas. Cancer Sci 94(9) 791-5(2003) 12967477 |
Hiai H, Tsuruyama T, Yamada Y. Pre-B lymphomas in SL/Kh mice: a multifactorial disease model. Cancer Sci 94(10) 847-50(2003) 14556656 |
Tsuruyama T, Hiratsuka T, Aini W, Nakamura T. STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. J Cell Biochem 117(11) 2630-42(2016) 27018255 |
Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H. Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis. Leuk Res 32(2) 309-14(2008) 17617450 |
Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene 35(25) 3227-38(2016) 26522721 |
Tsuruyama T, Liu W, Yoshikawa K. In vitro murine leukemia retroviral integration and structure fluctuation of target DNA. PLoS One 7(2) e31533(2012) 22348097 |
Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc Natl Acad Sci U S A 99(12) 8253-8(2002) 12048235 |
Hiai H. Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S. Springer-Verlag 227-244(2008) |
Tatsuaki Tsuruyama. DNA insertion mutations can be predicted by a periodic probability function. arXiv (2017) |