Strain Data Sheet



BRC No.RBRC00209
TypeWild-derived Inbred
SpeciesMus musculus molossinus
Strain nameMSM/Ms
Former Common nameM.MOL-MSM
H-2 Haplotype
ES Cell line
Background strainMSM [Mus musculus molossinus]
Appearancewhite-bellied agouti [Aw/Aw]
Strain developmentDeveloped by National Institute of Genetics.
Strain descriptionWild-derived inbred strain of Mus musculus molossinus, collected at Mishima, Shizuoka, Japan in April 1978 and maintained by Kazuo Mrowaki, National Institute of Genetics. This strain has been reported to be resistant to the development of lymphoma and obesity. MSM can be used to support research in many areas including cancer and genetics.
Colony maintenanceSibling x Sibling. Productive mating: 60.6% (n=53); First mating: 77.7 days (n=14); Litter size: 5.2 pups (n=102)
ReferencesProc. Natl. Acad. Sci. USA, 94, 10817-10820 (1997). 9380717
Exp. Anim., 58, 123-134 (2009). 19448335
Mamm. Genome, 12, 750-752 (2001). 11641725
Mamm. Genome, 20, 14-20(2009). 19082856
Genome Res., 18, 500-508 (2008). 18256237
Cancer Res., 56, 3716-3720 (1996). 12097280
Genome Res., 14, 2439-2447 (2004). 15574823
Acta Med. Okayama., 50, 319-324(1996). 8985469
Cancer Lett., 111, 97-104 (1997). 9022133
Exp. Anim., 44, 43-48 (1995). 7705478

Health Report

Examination Date / Room / Rack2022/03/15Room:4-CRack:F


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter


Donor DNA
Research applicationCancer Research
Genetics Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. (Contact info: Tsuyoshi Koide, Ph.D. <>, Mouse Genomics Resource Laboratory)
DepositorToshihiko Shiroishi (National Institute of Genetics)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityLive mouse (1 to 3 months)
Additional Info.Click Here for Mouse genomic DNA (RIKEN DNA Bank)
Click Here for BAC clone (RIKEN DNA Bank)
Mouse of the Month Apr 2009
Genetic Background
Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A.
Efficient Production of Offspring from Japanese Wild-Derived Strains of Mice (Mus musculus molossinus) by Improved Assisted Reproductive Technologies.
Biol. Reprod. (2012) 22337332

Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K.
Large, Male Germ Cell-Specific Hypomethylated DNA Domains With Unique Genomic and Epigenomic Features on the Mouse X Chromosome.
DNA Res. (2013) 23861320

Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H.
Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse.
Exp. Eye Res. 86(5) 828-34(2008) 18396277

Oka A, Mita A, Sakurai-Yamatani N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T.
Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies
Genetics 166(2) 913-924(2004) 15020476

Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H.
ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner.
Hum. Mol. Genet. (2011) 22156770

Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K.
Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain.
Mamm. Genome 20(1) 14-20(2009) 19082856

Nunome M, Ishimori C, Aplin KP, Tsuchiya K, Yonekawa H, Moriwaki K, Suzuki H.
Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice.
Mol. Ecol. 19(12) 2474-89(2010) 20465587

Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A.
Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection.
Mol. Reprod. Dev. 74(9) 1081-8(2007) 17290420

Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y.
Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation.
Nature 548(7666) 224-227(2017) 28746308

Sugimoto M, Abe K.
X chromosome reactivation initiates in nascent primordial germ cells in mice.
PLoS Genet. 3(7) e116(2007) 17676999

Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus.
PLoS ONE 9(12) e114305 e114305(2014) 25470728

Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A.
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Sci Rep 7 42476(2017) 28195201