Strain Data Sheet
RBRC00209
Information1 | |
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| Image |  |
| BRC No. | RBRC00209 |
| Type | Wild-derived Inbred |
| Species | Mus musculus molossinus |
| Strain name | MSM/Ms |
| Former Common name | M.MOL-MSM |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | MSM [Mus musculus molossinus] |
| Appearance | white-bellied agouti [Aw/Aw] |
| Strain development | Developed by National Institute of Genetics. |
| Strain description | Wild-derived inbred strain of Mus musculus molossinus, collected at Mishima, Shizuoka, Japan in April 1978 and maintained by Kazuo Mrowaki, National Institute of Genetics. This strain has been reported to be resistant to the development of lymphoma and obesity. MSM can be used to support research in many areas including cancer and genetics. |
| Colony maintenance | Sibling x Sibling. Productive mating: 60.6% (n=53); First mating: 77.7 days (n=14); Litter size: 5.2 pups (n=102) |
| References | Proc. Natl. Acad. Sci. USA, 94, 10817-10820 (1997). 9380717 Exp. Anim., 58, 123-134 (2009). 19448335 Mamm. Genome, 12, 750-752 (2001). 11641725 Mamm. Genome, 20, 14-20(2009). 19082856 Genome Res., 18, 500-508 (2008). 18256237 Cancer Res., 56, 3716-3720 (1996). 12097280 Genome Res., 14, 2439-2447 (2004). 15574823 Acta Med. Okayama., 50, 319-324(1996). 8985469 Cancer Lett., 111, 97-104 (1997). 9022133 Exp. Anim., 44, 43-48 (1995). 7705478 |
Health Report | |
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| Examination Date / Room / Rack | 2022/03/15Room:4-CRack:F 2021/12/13Room:4-CRack:F 2021/09/13Room:4-CRack:F 2021/06/14Room:4-CRack:F 2021/03/29Room:4-CRack:F 2021/01/05Room:4-CRack:F 2020/10/05Room:4-CRack:F 2020/07/06Room:4-CRack:F |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter null |
Information2 | |
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| Donor DNA | |
| Research application | Cancer Research Genetics Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. (Contact info: Tsuyoshi Koide, Ph.D. <tkoide@nig.ac.jp>, Mouse Genomics Resource Laboratory) |
| Depositor | Toshihiko Shiroishi (National Institute of Genetics) |
| Strain Status |  Live mice Frozen embryos Frozen sperm |
| Strain Availability | Live mouse (1 to 3 months) |
| Additional Info. | Click Here for Mouse genomic DNA (RIKEN DNA Bank) Click Here for BAC clone (RIKEN DNA Bank) Mouse of the Month Apr 2009 Genetic Background Necessary documents for ordering: |
BRC mice in Publications |
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Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A. Efficient Production of Offspring from Japanese Wild-Derived Strains of Mice (Mus musculus molossinus) by Improved Assisted Reproductive Technologies. Biol. Reprod. (2012) 22337332 Ikeda R, Shiura H, Numata K, Sugimoto M, Kondo M, Mise N, Suzuki M, Greally JM, Abe K. Large, Male Germ Cell-Specific Hypomethylated DNA Domains With Unique Genomic and Epigenomic Features on the Mouse X Chromosome. DNA Res. (2013) 23861320 Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp. Eye Res. 86(5) 828-34(2008) 18396277 Oka A, Mita A, Sakurai-Yamatani N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T. Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies Genetics 166(2) 913-924(2004) 15020476 Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H. ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner. Hum. Mol. Genet. (2011) 22156770 Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, Yamamura K. Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Mamm. Genome 20(1) 14-20(2009) 19082856 Nunome M, Ishimori C, Aplin KP, Tsuchiya K, Yonekawa H, Moriwaki K, Suzuki H. Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Mol. Ecol. 19(12) 2474-89(2010) 20465587 Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A. Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection. Mol. Reprod. Dev. 74(9) 1081-8(2007) 17290420 Yagi M, Kishigami S, Tanaka A, Semi K, Mizutani E, Wakayama S, Wakayama T, Yamamoto T, Yamada Y. Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation. Nature 548(7666) 224-227(2017) 28746308 Sugimoto M, Abe K. X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet. 3(7) e116(2007) 17676999 Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A. Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. PLoS ONE 9(12) e114305 e114305(2014) 25470728 Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A. CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Sci Rep 7 42476(2017) 28195201 |