BRC No.RBRC00193
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameGRS.Cg-Tnc<tm1Sia>/Rbrc
Former Common nameGRS/A-TgH(Tnc), GR-TNKO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainGRS/A
Appearancealbino [a/a, c/c]
Strain developmentThe original tenascin deficient mice with mixed genetic background was reported to develop normally without tenascin. To clarify the biological function of tenascin-C in vivo, several congenic strains with inbred background have been developed by Dr. Kusakabe M, Cell Biology Laboratory, Life Science Tsukuba Research Center, RIKEN since 1992.The tenascin-deficient congenic strains were thus developed by successive backcrossing into A, BALB/cA, C57BL/6N, C3H/HeN, and GRS/A.
Strain descriptionThis strain is useful to study the biological function of extracellular matrix tenascin-C in vivo, espacially in the field of tumor development, tumor metastasis, wound healing, tissue regeneration, angiogenesis, tissue interaction etc. Background strain, GRS/A have a high incidence of mammary tumours which are highly hormone-responsive in breeding females.
Colony maintenance
ReferencesJ. Comp. Neurol., 430, 485-500 (2001). 11169482
Biochem. Biophys. Res. Commun., 231, 356-359 (1997). 9070278
Biochem. Biophys. Res. Commun., 290, 1220-1227 (2002). 11811993
Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999). 10235540
J. Invest. Dermatol., 111, 930-935 (1998). 9856798
Biochem. Biophys. Res. Commun., 221, 151-156 (1996). 8660327
J. Neurosci., 15, 1971-1983 (1995). 7534342
Am. J. Pathol., 152, 1237-1245 (1998). 9588892
Genes Dev., 6, 1821-1831 (1992). 1383086
Perspect. Dev. Neurobiol., 2, 111-116 (1994). 7530137
Gene, 104, 177-185 (1991). 1717349
Exp. Mol. Pathol., 72, 186-195 (2002). 12009782

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tnctenascin C4Tnc<tm1Sia>targeted mutation 1, Shinichi Aizawa

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)4

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAE. coli lacZ, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), mouse tenascin genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Am. J. Pathol., 152, 1237-1245 (1998). J. Invest. Dermatol., 111, 930-935 (1998). Invest. Ophthalmol. Visual. Sci., 40, 1071-1080 (1999).
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data