RBRC00144

Information1

Image
BRC No.RBRC00144
TypeCongenic
SpeciesMus musculus
Strain nameC57BL/6-Ly5.1
Former Common nameC57BL/6-Ly-5.1
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain developmentDeposited by Toshitada Takahashi, Aichi Cancer Center.
Strain descriptionThis is a B6 background congenic strain that having differential B cell antigen designated as Ly5.1. This strain is useful as tissue/cell and B cell markers in transplantation studies.
Colony maintenanceHomozygote x Homozygote
References

Health Report

Examination Date / Room / Rack2020/06/01Room:3-ARack:H
2020/02/17Room:3-ARack:H
2019/12/16Room:3-ARack:H
2019/10/21Room:3-ARack:H
2019/08/26Room:3-ARack:H
2019/06/17Room:3-ARack:H
2019/04/15Room:3-ARack:H
2019/02/18Room:3-ARack:H

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Ptprcprotein tyrosine phosphatase, receptor type, C1Ptprc<a>a variant

Information2

Donor DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorToshitada Takahashi (Aichi Cancer Center)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Jun 2009
Genetic Background

BRC mice in Publications

Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K.
Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice
Arterioscler. Thromb. Vasc. Biol. 36 1141(2016) 27055906

Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H.
Fucci-guided purification of hematopoietic stem cells with high repopulating activity.
Biochem. Biophys. Res. Commun. (2014) 25534850

Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A.
Mature resting Ly6Chigh natural killer cells can be reactivated by IL 15.
Eur. J. Immunol. 44(9) 2638-47.(2014) 24995967

Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T.
The development of IL-17/IFN-gamma-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.
Eur. J. Immunol. (2012) 22674086

Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H.
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells.
FEBS Lett. 584(15) 547377(2010) 20600007

Eiko Saijou Yutaka Enomoto Michitaka Matsuda Cindy Yuet‐Yin Kok Shizuo Akira Minoru Tanaka Atsushi Miyajima.
Neutrophils alleviate fibrosis in the CCl4‐induced mouse chronic liver injury model.
Hepatol Commun (2018) 29881822

Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T.
Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): Preparation and immunological analysis of vaccine efficacy.
Immunol. Lett. (2014) 25479286

Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
NF-kappaB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain hematopoietic niche after lethal irradiation and stem cell transplantation.
Int. Immunol. (2014) 24908679

Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H.
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
Int. Immunol. (2013) 24150243

Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K.
Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.
Int. Immunol. 23(1) 65-74(2011) 21135032

Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T.
IL-17/IFN-gamma double producing CD8+ T (Tc17/IFN-gamma) cells: A novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
Int. Immunol. (2011) 22039016

Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H.
Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6.
Int. J. Hematol. 87(3) 239-45(2008) 18317883

Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H.
Inflammasome and Fas-Mediated IL-1beta Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo.
J. Immunol. 199(3) 1122-1130(2017) 28674179

Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS.
The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation.
J. Immunol. 182(8) 1098071(2009) 19342670

Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S.
Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes.
Mucosal Immunol (2016) 27166558

Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T.
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.
Nat Commun 4 1836(2013) 23673621

Noda S, Horiguchi K, Ichikawa H, Miyoshi H.
Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population.
Stem Cells 26(3) 646-55(2008) 18079432