Strain Data Sheet

RBRC00144

update : 2023-05-22

Information1
Image
BRC No.	RBRC00144
Type	Congenic
Species	Mus musculus
Strain name	B6.SJL-Ptprc<a>/Rbrc
Former Common name	C57BL/6-Ly-5.1
H-2 Haplotype
ES Cell line
Background strain	C57BL/6
Appearance	black [a/a B/B C/C]
Strain development	Deposited by Toshitada Takahashi, Aichi Cancer Center.
Strain description	This is a B6 background congenic strain that having differential B cell antigen designated as Ly5.1. This strain is useful as tissue/cell and B cell markers in transplantation studies.
Colony maintenance	Homozygote x Homozygote
References

Health Report
Examination Date / Room / Rack	2023/04/10Room:3-ARack:H 2023/01/10Room:3-ARack:H 2022/10/11Room:3-ARack:H 2022/07/11Room:3-ARack:H 2022/05/16Room:3-ARack:H 2022/04/11Room:3-ARack:H 2022/01/24Room:3-ARack:H 2021/10/26Room:3-ARack:H 2021/07/26Room:3-ARack:H

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Ptprcprotein tyrosine phosphatase, receptor type, C1Ptprc<a>a variantB220, CD45, Cd45, CD45R, Ly-5, LY-5, Lyt-4, T200, CD45.1

Information2
Donor DNA
Research application	Immunology and Inflammation Research
Specific Term and Conditions	No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Depositor	Toshitada Takahashi (Aichi Cancer Center)
Strain Status	Live mice Frozen embryos Frozen sperm
Strain Availability	Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months)
Additional Info.	Mouse of the Month Jun 2009 Genetic Background Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Genotyping protocol -PCR-

BRC mice in Publications

Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K. Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol 36(6) 1141-51(2016) 27055906 Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H. Fucci-guided purification of hematopoietic stem cells with high repopulating activity. Biochem Biophys Res Commun 457(1) 7-11(2015) 25534850 Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A. Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15. Eur J Immunol 44(9) 2638-47(2014) 24995967 Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T. The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter. Eur J Immunol 42(9) 2329-42(2012) 22674086 Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H. Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett 584(15) 3402-9(2010) 20600007 Saijou E, Enomoto Y, Matsuda M, Yuet-Yin Kok C, Akira S, Tanaka M, Miyajima A. Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model. Hepatol Commun 2(6) 703-717(2018) 29881822 Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI. Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells. Immunohorizons 5(6) 424-437(2021) 34112701 Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T. Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy. Immunol Lett 163(1) 102-12(2015) 25479286 Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H. Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol 26(2) 103-14(2014) 24150243 Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T. NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int Immunol 26(11) 607-18(2014) 24908679 Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T. IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12. Int Immunol 23(12) 751-9(2011) 22039016 Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K. Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells. Int Immunol 23(1) 65-74(2011) 21135032 Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H. Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6. Int J Hematol 87(3) 239-45(2008) 18317883 Hosaka N, Kanda S, Shimono T, Nishiyama T. Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells. J Cell Mol Med 25(22) 10604-10613(2021) 34687276 Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H. Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo. J Immunol 199(3) 1122-1130(2017) 28674179 Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS. The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation. J Immunol 182(8) 4910-6(2009) 19342670 Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S. Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes. Mucosal Immunol 10(1) 79-90(2017) 27166558 Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T. PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun 4 1836(2013) 23673621 Kuroishi T, Bando K, Bakti RK, Ouchi G, Tanaka Y, Sugawara S. Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities. Sci Rep 10(1) 5050(2020) 32193426 Noda S, Horiguchi K, Ichikawa H, Miyoshi H. Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. Stem Cells 26(3) 646-55(2008) 18079432

BRC mice in Publications

Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K.
Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice.
Arterioscler Thromb Vasc Biol 36(6) 1141-51(2016) 27055906

Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H.
Fucci-guided purification of hematopoietic stem cells with high repopulating activity.
Biochem Biophys Res Commun 457(1) 7-11(2015) 25534850

Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A.
Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15.
Eur J Immunol 44(9) 2638-47(2014) 24995967

Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T.
The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.
Eur J Immunol 42(9) 2329-42(2012) 22674086

Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H.
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells.
FEBS Lett 584(15) 3402-9(2010) 20600007

Saijou E, Enomoto Y, Matsuda M, Yuet-Yin Kok C, Akira S, Tanaka M, Miyajima A.
Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model.
Hepatol Commun 2(6) 703-717(2018) 29881822

Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI.
Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells.
Immunohorizons 5(6) 424-437(2021) 34112701

Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T.
Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy.
Immunol Lett 163(1) 102-12(2015) 25479286

Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H.
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
Int Immunol 26(2) 103-14(2014) 24150243

Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation.
Int Immunol 26(11) 607-18(2014) 24908679

Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T.
IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
Int Immunol 23(12) 751-9(2011) 22039016

Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K.
Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.
Int Immunol 23(1) 65-74(2011) 21135032

Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H.
Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6.
Int J Hematol 87(3) 239-45(2008) 18317883

Hosaka N, Kanda S, Shimono T, Nishiyama T.
Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells.
J Cell Mol Med 25(22) 10604-10613(2021) 34687276

Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H.
Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo.
J Immunol 199(3) 1122-1130(2017) 28674179

Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS.
The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation.
J Immunol 182(8) 4910-6(2009) 19342670

Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S.
Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes.
Mucosal Immunol 10(1) 79-90(2017) 27166558

Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T.
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.
Nat Commun 4 1836(2013) 23673621

Kuroishi T, Bando K, Bakti RK, Ouchi G, Tanaka Y, Sugawara S.
Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities.
Sci Rep 10(1) 5050(2020) 32193426

Noda S, Horiguchi K, Ichikawa H, Miyoshi H.
Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population.
Stem Cells 26(3) 646-55(2008) 18079432

Information1

Health Report

Gene

Information2

BRC mice in Publications